Kavitha Gnanasambandan, Ph.D.
Affiliations: | 2011 | University of Florida, Gainesville, Gainesville, FL, United States |
Area:
Biochemistry, Pharmacology, Bioinformatics BiologyGoogle:
"Kavitha Gnanasambandan"Mean distance: (not calculated yet)
Parents
Sign in to add mentor| Peter P. Sayeski | grad student | 2011 | UF Gainesville | |
| (Molecular mechanisms for the constitutive activation of Jak2 mutations.) | ||||
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Publications
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| Shevell LM, Lee E, Dhodapkar R, et al. (2018) Whole Exome Sequencing and Extended Thrombophilia Testing in Patients with Venous Thromboembolism Blood. 132: 2506-2506 |
| Lee EJ, Dykas DJ, Leavitt AD, et al. (2017) Whole-exome sequencing in evaluation of patients with venous thromboembolism. Blood Advances. 1: 1224-1237 |
| Shan Y, Gnanasambandan K, Ungureanu D, et al. (2014) Molecular basis for pseudokinase-dependent autoinhibition of JAK2 tyrosine kinase. Nature Structural & Molecular Biology. 21: 579-84 |
| Hubbard SR, Gnanasambandan K. (2013) Structure and activation of MuSK, a receptor tyrosine kinase central to neuromuscular junction formation. Biochimica Et Biophysica Acta. 1834: 2166-9 |
| Gnanasambandan K, Magis AT, Sayeski PP. (2012) A shift in the salt bridge interaction of residues D620 and E621 mediates the constitutive activation of Jak2-H538Q/K539L. Molecular and Cellular Biochemistry. 367: 125-40 |
| Gnanasambandan K, Sayeski PP. (2011) A structure-function perspective of Jak2 mutations and implications for alternate drug design strategies: the road not taken. Current Medicinal Chemistry. 18: 4659-73 |
| Sayyah J, Gnanasambandan K, Kamarajugadda S, et al. (2011) Phosphorylation of Y372 is critical for Jak2 tyrosine kinase activation. Cellular Signalling. 23: 1806-15 |
| Gnanasambandan K, Magis A, Sayeski PP. (2010) The constitutive activation of Jak2-V617F is mediated by a π stacking mechanism involving phenylalanines 595 and 617. Biochemistry. 49: 9972-84 |
| Park S, Gnanasambandan K, Sayeski PP. (2010) Jak2 Plays a Critical and Non-Redundant Role In Hematopoiesis throughout Pre- and Post-Natal Life Blood. 116: 2238-2238 |