Perry A. Frey

Affiliations: 
Biochemistry University of Wisconsin, Madison, Madison, WI 
Area:
Mechanisms of enzyme and coenzyme action; stereochemistry and mechanisms of phospho- and nucleotidyl transferase action; structure and function of multienzyme complexes
Website:
http://www.biochem.wisc.edu/faculty/frey/
Google:
"Perry Frey"
Bio:

http://www.nasonline.org/member-directory/members/1314.html

Mean distance: 7.37
 
SNBCP

Parents

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Robert Heinz Abeles grad student 1968 Brandeis
 (Studies on the mechanism of the dioldehydrase reaction and the role of vitamin B₁₂ coenzyme)
Frank H. Westheimer post-doc Harvard

Children

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Thomas J. Meade research assistant 1982 Ohio State
Olafur T. Magnusson grad student 2001 UW Madison
Adrian D. Hegeman grad student 1995-2001 UW Madison
Kuo-Hsiang Tang grad student 2002 UW Madison
Glen T. Hinckley grad student 2005 UW Madison
Phillip A. Schwartz grad student 2006 UW Madison
Squire J. Booker post-doc 1996-1999 UW Madison
BETA: Related publications

Publications

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Frey PA. (2014) Travels with carbon-centered radicals. 5'-deoxyadenosine and 5'-deoxyadenosine-5'-yl in radical enzymology. Accounts of Chemical Research. 47: 540-9
Frey PA, Hegeman AD. (2013) Chemical and stereochemical actions of UDP-galactose 4-epimerase. Accounts of Chemical Research. 46: 1417-26
Chen YH, Maity AN, Frey PA, et al. (2013) Mechanism-based inhibition reveals transitions between two conformational states in the action of lysine 5,6-aminomutase: a combination of electron paramagnetic resonance spectroscopy, electron nuclear double resonance spectroscopy, and density functional theory study. Journal of the American Chemical Society. 135: 788-94
Frey PA, Reed GH. (2012) The ubiquity of iron. Acs Chemical Biology. 7: 1477-81
Chen YH, Maity AN, Pan YC, et al. (2011) Radical stabilization is crucial in the mechanism of action of lysine 5,6-aminomutase: role of tyrosine-263α as revealed by electron paramagnetic resonance spectroscopy. Journal of the American Chemical Society. 133: 17152-5
Frey PA, Reed GH. (2011) Pyridoxal-5'-phosphate as the catalyst for radical isomerization in reactions of PLP-dependent aminomutases. Biochimica Et Biophysica Acta. 1814: 1548-57
Frey PA, Outten CE. (2011) Forging ahead: new mechanistic insights into iron biochemistry. Current Opinion in Chemical Biology. 15: 257-9
Ruzicka FJ, Frey PA. (2010) Kinetic and spectroscopic evidence of negative cooperativity in the action of lysine 2,3-aminomutase. The Journal of Physical Chemistry. B. 114: 16118-24
Frey PA. (2010) Sulfur as a mechanistic probe in enzymatic and non-enzymatic substitution at phosphorus New Journal of Chemistry. 34: 820-828
Frey PA. (2010) Cobalamin coenzymes in enzymology Comprehensive Natural Products Ii: Chemistry and Biology. 7: 501-546
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