Perry A. Frey

Biochemistry University of Wisconsin, Madison, Madison, WI 
Mechanisms of enzyme and coenzyme action; stereochemistry and mechanisms of phospho- and nucleotidyl transferase action; structure and function of multienzyme complexes
"Perry Frey"

Mean distance: 7.37


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Robert Heinz Abeles grad student 1968 Brandeis
 (Studies on the mechanism of the dioldehydrase reaction and the role of vitamin B₁₂ coenzyme)
Frank H. Westheimer post-doc Harvard


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Thomas J. Meade research assistant 1982 Ohio State
John P. Richard grad student 1979 Ohio State (Crystallography Tree)
Olafur T. Magnusson grad student 2001 UW Madison
Adrian D. Hegeman grad student 1995-2001 UW Madison
Kuo-Hsiang Tang grad student 2002 UW Madison
Glen T. Hinckley grad student 2005 UW Madison
Phillip A. Schwartz grad student 2006 UW Madison
Squire J. Booker post-doc 1996-1999 UW Madison
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Ngo PD, Mansoorabadi SO, Frey PA. (2016) Serine Protease Catalysis: A Computational Study of Tetrahedral Intermediates and Inhibitory Adducts. The Journal of Physical Chemistry. B
Frey PA. (2014) Travels with carbon-centered radicals. 5'-deoxyadenosine and 5'-deoxyadenosine-5'-yl in radical enzymology. Accounts of Chemical Research. 47: 540-9
Frey PA, Hegeman AD. (2013) Chemical and stereochemical actions of UDP-galactose 4-epimerase. Accounts of Chemical Research. 46: 1417-26
Chen YH, Maity AN, Frey PA, et al. (2013) Mechanism-based inhibition reveals transitions between two conformational states in the action of lysine 5,6-aminomutase: a combination of electron paramagnetic resonance spectroscopy, electron nuclear double resonance spectroscopy, and density functional theory study. Journal of the American Chemical Society. 135: 788-94
Frey PA, Reed GH. (2012) The ubiquity of iron. Acs Chemical Biology. 7: 1477-81
Chen YH, Maity AN, Pan YC, et al. (2011) Radical stabilization is crucial in the mechanism of action of lysine 5,6-aminomutase: role of tyrosine-263α as revealed by electron paramagnetic resonance spectroscopy. Journal of the American Chemical Society. 133: 17152-5
Frey PA, Reed GH. (2011) Pyridoxal-5'-phosphate as the catalyst for radical isomerization in reactions of PLP-dependent aminomutases. Biochimica Et Biophysica Acta. 1814: 1548-57
Frey PA, Outten CE. (2011) Forging ahead: new mechanistic insights into iron biochemistry. Current Opinion in Chemical Biology. 15: 257-9
Ruzicka FJ, Frey PA. (2010) Kinetic and spectroscopic evidence of negative cooperativity in the action of lysine 2,3-aminomutase. The Journal of Physical Chemistry. B. 114: 16118-24
Frey PA. (2010) Sulfur as a mechanistic probe in enzymatic and non-enzymatic substitution at phosphorus New Journal of Chemistry. 34: 820-828
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