Hilal A. Lashuel, Ph. D.

Affiliations: 
Molecular and Chemical Biology École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland 
Area:
Neurodegeneration
Website:
http://lashuel-lab.epfl.ch/page-18616-en.html
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"Hilal Lashuel"
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Parents

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Jeffery W. Kelly grad student 1994-1999 Texas A & M
 (Biophysical studies on the acid denaturation of transthyretin: Understanding the mechanism of fibril formation in human amyloid disease.)
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Publications

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Lashuel HA, Novello S. (2021) Lewy body-associated proteins: Victims, instigators, or innocent bystanders? The case of AIMP2 and alpha-synuclein. Neurobiology of Disease. 105417
Dikiy I, Fauvet B, Jovičić A, et al. (2016) Semisynthetic and in vitro phosphorylation of alpha-synuclein at Y39 promotes functional partly-helical membrane-bound states resembling those induced by PD mutations. Acs Chemical Biology
Fares MB, Maco B, Oueslati A, et al. (2016) Induction of de novo α-synuclein fibrillization in a neuronal model for Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America
Fauvet B, Lashuel HA. (2016) Semisynthesis and Enzymatic Preparation of Post-translationally Modified α-Synuclein. Methods in Molecular Biology (Clifton, N.J.). 1345: 3-20
Adamcik J, Sánchez-Ferrer A, Ait-Bouziad N, et al. (2015) Microtubule-Binding R3 Fragment from Tau Self-Assembles into Giant Multistranded Amyloid Ribbons. Angewandte Chemie (International Ed. in English)
Oueslati A, Lovisa B, Perrin J, et al. (2015) Photobiomodulation Suppresses Alpha-Synuclein-Induced Toxicity in an AAV-Based Rat Genetic Model of Parkinson's Disease. Plos One. 10: e0140880
Mahul-Mellier AL, Vercruysse F, Maco B, et al. (2015) Fibril growth and seeding capacity play key roles in α-synuclein-mediated apoptotic cell death. Cell Death and Differentiation
Bustamante MB, Ansaloni A, Pedersen JF, et al. (2015) Detection of huntingtin exon 1 phosphorylation by Phos-Tag SDS-PAGE: Predominant phosphorylation on Threonine 3 and regulation by IKKβ. Biochemical and Biophysical Research Communications
Burai R, Ait-Bouziad N, Chiki A, et al. (2015) Elucidating the Role of Site-Specific Nitration of α-Synuclein in the Pathogenesis of Parkinson's Disease via Protein Semisynthesis and Mutagenesis. Journal of the American Chemical Society. 137: 5041-52
Mbefo MK, Fares MB, Paleologou K, et al. (2015) Parkinson disease mutant E46K enhances α-synuclein phosphorylation in mammalian cell lines, in yeast, and in vivo. The Journal of Biological Chemistry. 290: 9412-27
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