Rockland Luke Wiseman, Ph.D.

Molecular and Experimental Medicine Scripps Research Institute, La Jolla, La Jolla, CA, United States 
Cellular Protein Homeostasis
"Rockland Wiseman"
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Puchades C, Ding B, Song A, et al. (2019) Unique Structural Features of the Mitochondrial AAA+ Protease AFG3L2 Reveal the Molecular Basis for Activity in Health and Disease. Molecular Cell
Plate L, Rius B, Nguyen B, et al. (2019) Quantitative Interactome Proteomics Reveals a Molecular Basis for ATF6-Dependent Regulation of a Destabilized Amyloidogenic Protein. Cell Chemical Biology
Glembotski CC, Rosarda JD, Wiseman RL. (2019) Proteostasis and Beyond: ATF6 in Ischemic Disease. Trends in Molecular Medicine
Grandjean JMD, Plate L, Morimoto RI, et al. (2019) Deconvoluting Stress-Responsive Proteostasis Signaling Pathways for Pharmacologic Activation using Targeted RNA-sequencing. Acs Chemical Biology
Blackwood EA, Azizi K, Thuerauf DJ, et al. (2019) Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis. Nature Communications. 10: 187
Paxman R, Plate L, Blackwood EA, et al. (2018) Pharmacologic ATF6 activating compounds are metabolically activated to selectively modify endoplasmic reticulum proteins. Elife. 7
Kroeger H, Grimsey N, Paxman R, et al. (2018) The unfolded protein response regulator ATF6 promotes mesodermal differentiation. Science Signaling. 11
Puchades C, Rampello AJ, Shin M, et al. (2017) Structure of the mitochondrial inner membrane AAA+ protease YME1 gives insight into substrate processing. Science (New York, N.Y.). 358
Chen KC, Qu S, Chowdhury S, et al. (2017) The endoplasmic reticulum HSP40 co-chaperone ERdj3/DNAJB11 assembles and functions as a tetramer. The Embo Journal
Plate L, Wiseman RL. (2017) Regulating Secretory Proteostasis through the Unfolded Protein Response: From Function to Therapy. Trends in Cell Biology
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