Douglas S. Williams

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2003-2007 University of Pennsylvania, Philadelphia, PA, United States 
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"Douglas Williams"
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Eric Meggers grad student 2003-2008 Penn
 (From ruthenium to platinum: The development of organometallic complexes for use as enzyme inhibitors.)
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Xie P, Williams DS, Atilla-Gokcumen GE, et al. (2008) Structure-based design of an organoruthenium phosphatidyl-inositol-3-kinase inhibitor reveals a switch governing lipid kinase potency and selectivity. Acs Chemical Biology. 3: 305-16
Maksimoska J, Williams DS, Atilla-Gokcumen GE, et al. (2008) Similar biological activities of two isostructural ruthenium and osmium complexes. Chemistry (Weinheim An Der Bergstrasse, Germany). 14: 4816-22
Pagano N, Maksimoska J, Bregman H, et al. (2007) Ruthenium half-sandwich complexes as protein kinase inhibitors: derivatization of the pyridocarbazole pharmacophore ligand. Organic & Biomolecular Chemistry. 5: 1218-27
Williams DS, Carroll PJ, Meggers E. (2007) Platinum complex as a nanomolar protein kinase inhibitor. Inorganic Chemistry. 46: 2944-6
Smalley KS, Contractor R, Haass NK, et al. (2007) An organometallic protein kinase inhibitor pharmacologically activates p53 and induces apoptosis in human melanoma cells. Cancer Research. 67: 209-17
Atilla-Gokcumen GE, Williams DS, Bregman H, et al. (2006) Organometallic compounds with biological activity: a very selective and highly potent cellular inhibitor for glycogen synthase kinase 3. Chembiochem : a European Journal of Chemical Biology. 7: 1443-50
Debreczeni JE, Bullock AN, Atilla GE, et al. (2006) Ruthenium half-sandwich complexes bound to protein kinase Pim-1. Angewandte Chemie (International Ed. in English). 45: 1580-5
Williams DS, Atilla GE, Bregman H, et al. (2005) Switching on a signaling pathway with an organoruthenium complex. Angewandte Chemie (International Ed. in English). 44: 1984-7
Bregman H, Williams DS, Atilla GE, et al. (2004) An organometallic inhibitor for glycogen synthase kinase 3. Journal of the American Chemical Society. 126: 13594-5
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