Douglas S. Williams
Affiliations: | 2003-2007 | University of Pennsylvania, Philadelphia, PA, United States |
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Parents
Sign in to add mentor| Eric Meggers | grad student | 2003-2008 | Penn | |
| (From ruthenium to platinum: The development of organometallic complexes for use as enzyme inhibitors.) | ||||
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| Xie P, Williams DS, Atilla-Gokcumen GE, et al. (2008) Structure-based design of an organoruthenium phosphatidyl-inositol-3-kinase inhibitor reveals a switch governing lipid kinase potency and selectivity. Acs Chemical Biology. 3: 305-16 |
| Maksimoska J, Williams DS, Atilla-Gokcumen GE, et al. (2008) Similar biological activities of two isostructural ruthenium and osmium complexes. Chemistry (Weinheim An Der Bergstrasse, Germany). 14: 4816-22 |
| Pagano N, Maksimoska J, Bregman H, et al. (2007) Ruthenium half-sandwich complexes as protein kinase inhibitors: derivatization of the pyridocarbazole pharmacophore ligand. Organic & Biomolecular Chemistry. 5: 1218-27 |
| Williams DS, Carroll PJ, Meggers E. (2007) Platinum complex as a nanomolar protein kinase inhibitor. Inorganic Chemistry. 46: 2944-6 |
| Smalley KS, Contractor R, Haass NK, et al. (2007) An organometallic protein kinase inhibitor pharmacologically activates p53 and induces apoptosis in human melanoma cells. Cancer Research. 67: 209-17 |
| Meggers E, Atilla-Gokcumen GE, Bregman H, et al. (2007) Exploring chemical space with organometallics: Ruthenium complexes as protein kinase inhibitors Synlett. 1177-1189 |
| Meggers E, Atilla-Gokcumen GE, Bregman H, et al. (2007) Exploring Chemical Space with Organometallics: Ruthenium Complexes as Protein Kinase Inhibitors Cheminform. 38 |
| Atilla-Gokcumen GE, Williams DS, Bregman H, et al. (2006) Organometallic compounds with biological activity: a very selective and highly potent cellular inhibitor for glycogen synthase kinase 3. Chembiochem : a European Journal of Chemical Biology. 7: 1443-50 |
| Debreczeni JE, Bullock AN, Atilla GE, et al. (2006) Ruthenium half-sandwich complexes bound to protein kinase Pim-1. Angewandte Chemie (International Ed. in English). 45: 1580-5 |
| Debreczeni JÉ, Bullock AN, Atilla GE, et al. (2006) Ruthenium Half-Sandwich Complexes Bound to Protein Kinase Pim-1 Angewandte Chemie. 118: 1610-1615 |