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Carrie Haskell-Luevano

Medicinal Chemistry University of Minnesota, Twin Cities, Minneapolis, MN 
peptide hormone endocrine systems in the brain, and their involvement in feeding behavior, exercise, diabetes, and obesity
"Carrie Haskell-Luevano"
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Ericson MD, Larson CM, Freeman KT, et al. (2022) Incorporation of Indoylated Phenylalanine Yields a Sub-Micromolar Selective Melanocortin-4 Receptor Antagonist Tetrapeptide. Acs Omega. 7: 27656-27663
Ericson MD, Doering SR, Larson CM, et al. (2021) Functional Mixture-Based Positional Scan Identifies a Library of Antagonist Tetrapeptide Sequences (LAtTeS) with Nanomolar Potency for the Melanocortin-4 Receptor and Equipotent with the Endogenous AGRP(86-132) Antagonist. Journal of Medicinal Chemistry
Doering SR, Freeman K, Debevec G, et al. (2021) Discovery of Nanomolar Melanocortin-3 Receptor (MC3R)-Selective Small Molecule Pyrrolidine Bis-Cyclic Guanidine Agonist Compounds Via a High-Throughput "Unbiased" Screening Campaign. Journal of Medicinal Chemistry
Koikov L, Starner RJ, Swope VB, et al. (2021) Development of hMC1R Selective Small Agonists for Sunless Tanning and Prevention of Genotoxicity of UV in Melanocytes. The Journal of Investigative Dermatology
Ericson MD, Shaikh R, Larson CM, et al. (2021) Multiresidue Tetrapeptide Substitutions Yield a 140-fold Selective Melanocortin-3 over Melanocortin-4 Receptor Agonist. Acs Medicinal Chemistry Letters. 12: 115-120
Ericson MD, Haslach EM, Schnell SM, et al. (2021) Discovery of Molecular Interactions of the Human Melanocortin-4 Receptor (hMC4R) Asp189 (D189) Amino Acid with the Endogenous G-Protein-Coupled Receptor (GPCR) Antagonist Agouti-Related Protein (AGRP) Provides Insights to AGRP's Inverse Agonist Pharmacology at the hMC4R. Acs Chemical Neuroscience. 12: 542-556
Ericson MD, Freeman KT, Haskell-Luevano C. (2020) Peptoid NPhe in AGRP-Based c[Pro-Arg-Phe-Phe-Xxx-Ala-Phe-DPro] Scaffolds Maintain Mouse MC4R Antagonist Potency. Acs Medicinal Chemistry Letters. 11: 1942-1948
Adank DN, Lunzer MM, Ericson MD, et al. (2020) Comparative intracerebroventricular (ICV) and intrathecal (IT) administration of a nanomolar macrocyclic melanocortin receptor agonist MDE6-5-2c (c[Pro-His-DPhe-Arg-Trp-Dap-Ala-DPro]) decreases food intake in mice. Acs Chemical Neuroscience
Winget MD, Ericson MD, Freeman KT, et al. (2020) Single Nucleotide Polymorphisms in the Melanocortin His-Phe-Arg-Trp Sequences Decrease Tetrapeptide Potency and Efficacy. Acs Medicinal Chemistry Letters. 11: 272-277
Koerperich ZM, Ericson MD, Freeman KT, et al. (2019) Incorporation of Agouti-Related Protein (AgRP) Human Single Nucleotide Polymorphisms (SNPs) in the AGRP-Derived Macrocyclic Scaffold c[Pro-Arg-Phe-Phe-Asn-Ala-Phe-DPro] Decreases Melanocortin-4 Receptor Antagonist Potency and Results in the Discovery of Melanocortin-5 Receptor Antagonists. Journal of Medicinal Chemistry
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