William F. DeGrado, Ph.D.
Affiliations: | 1996-2011 | University of Pennsylvania, Philadelphia, PA, United States | |
2011- | Pharmaceutical Chemistry | University of California, San Francisco, San Francisco, CA |
Area:
Organic Chemistry, Chemical Biology, De Novo Protein DesignWebsite:
http://www.degradolab.org/index.phpGoogle:
"William DeGrado"Bio:
http://www.nasonline.org/member-directory/members/3008580.html
http://pharmchem.ucsf.edu/faculty/bios/william.degrado.html
https://pharm.ucsf.edu/degrado/people/alumni
Mean distance: 7.3 | S | N | B | C | P |
Parents
Sign in to add mentorEmil Thomas Kaiser | grad student | 1981 | Chicago | |
(Design, synthesis, and mechanism of action of a model cytotoxic peptide) |
Children
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Publications
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Zhang MY, Yang H, Ortiz G, et al. (2022) Covalent labeling of a chromatin reader domain using proximity-reactive cyclic peptides. Chemical Science. 13: 6599-6609 |
Kratochvil HT, Newberry RW, Mensa B, et al. (2021) Spiers Memorial Lecture: Analysis and design of membrane-interactive peptides. Faraday Discussions |
Thomaston JL, Samways ML, Konstantinidi A, et al. (2021) Rimantadine Binds to and Inhibits the Influenza A M2 Proton Channel without Enantiomeric Specificity. Biochemistry |
Scott AJ, Niitsu A, Kratochvil HT, et al. (2021) Constructing ion channels from water-soluble α-helical barrels. Nature Chemistry |
Naudin EA, McEwen AG, Tan SK, et al. (2021) Acyl Transfer Catalytic Activity in De Novo Designed Protein with N-Terminus of α-Helix As Oxyanion-Binding Site. Journal of the American Chemical Society |
Boyce JH, Dang B, Ary B, et al. (2020) Platform to Discover Protease-Activated Antibiotics and Application to Siderophore-Antibiotic Conjugates. Journal of the American Chemical Society |
Sundaram A, Chen C, Isik Reed N, et al. (2020) Dual antagonists of α5β1/ αvβ1 integrin for airway hyperresponsiveness. Bioorganic & Medicinal Chemistry Letters. 127578 |
Watkins LC, DeGrado WF, Voth GA. (2020) Influenza A M2 Inhibitor Binding Understood through Mechanisms of Excess Proton Stabilization and Channel Dynamics. Journal of the American Chemical Society. 142: 17425-17433 |
Polizzi NF, DeGrado WF. (2020) A defined structural unit enables de novo design of small-molecule-binding proteins. Science (New York, N.Y.). 369: 1227-1233 |
Newberry RW, Arhar T, Costello J, et al. (2020) Robust Sequence Determinants of α-Synuclein Toxicity in Yeast Implicate Membrane Binding. Acs Chemical Biology |