☰

William F. DeGrado, Ph.D.

Affiliations: 
1996-2011 University of Pennsylvania, Philadelphia, PA, United States 
 2011- Pharmaceutical Chemistry University of California, San Francisco, San Francisco, CA 
Area:
Organic Chemistry, Chemical Biology, De Novo Protein Design
Website:
http://www.degradolab.org/index.php
Google:
"William DeGrado"
Bio:

http://www.nasonline.org/member-directory/members/3008580.html
http://pharmchem.ucsf.edu/faculty/bios/william.degrado.html
https://pharm.ucsf.edu/degrado/people/alumni

Mean distance: 7.3
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Parents

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Emil Thomas Kaiser grad student 1981 Chicago
 (Design, synthesis, and mechanism of action of a model cytotoxic peptide)

Children

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Scott T. Walsh grad student 2000 Penn
Holly A. Gratkowski grad student 2002 Penn
Christopher M. Summa grad student 2002 Penn
Wai L. Lau grad student 2003 Penn
Avram M. Slovic grad student 2004 Penn
Jennifer R. Calhoun grad student 2006 Penn
Donald E. Engel grad student 2006 Penn
Benjamin H. North grad student 2006 Penn
Rachel S. Signarvic grad student 2006 Penn
Amanda L. Stouffer grad student 2006 Penn
Joanna S. Slusky grad student 2007 Penn
Gretchen M. Bender grad student 2008 Penn
Meredith W. Miller grad student 2008 Penn
Douglas G. Metcalf grad student 2009 Penn
Alexei Polishchuk grad student 2009 Penn
Scott J. Shandler grad student 2009 Penn
Daniel W. Kulp grad student 2010 Penn
Jun Wang grad student 2006-2010 Penn
Yao Zhang grad student 2011 Penn
Graham D. Clinthorne grad student 2012 Penn
Geronda L. Montalvo grad student 2012 Penn
Chaim A. Schramm grad student 2012 Penn
Gabriel B. Gonzalez grad student 2013 Penn
Brett T. Hannigan grad student 2013 Penn
Shao-Qing Zhang grad student 2013 Penn
Jonathan H Boyce post-doc UCSF
Kui Zhang post-doc 2018- UCSF
Hyunjun Yang post-doc 2019- UCSF
Lynne Joy Regan post-doc 1986-1988 DuPont Central Research and Development
Normand Voyer post-doc 1986-1988 DuPont Central Research and Development
Tracy M. Handel post-doc 1988-1991 DuPont Central Research and Development
Spencer J. Anthony-Cahill post-doc 1990-1992 DuPont Central Research and Development
Karin S. Åkerfeldt post-doc 1990-1993 DuPont Merck Pharmaceuticals Company
Robert Fairman post-doc 1990-1993 DuPont Merck Pharmaceuticals Company
Daniel P. Raleigh post-doc 1991-1993 DuPont Merck Pharmaceuticals Company
Stephen F Betz post-doc 1993-1996 DuPont Merck Pharmaceuticals Company
Gregg R. Dieckmann post-doc 1995-1999 Penn
R. Blake Hill post-doc 1995-2000 Penn
Joel P. Schneider post-doc 1995-2000 Penn
Paul A Dalby post-doc 1998-2000 University of Pennsylvania School of Medicine
Gregory N. Tew post-doc 2000-2001 Penn
Giovanna Ghirlanda post-doc 1996-2002 Penn
Richard P. Cheng post-doc 1998-2002 Penn
Renhao Li post-doc 1999-2003 Penn
Vikas Nanda post-doc 2001-2005 Penn
Jennifer Rachel Cochran post-doc 2004-2005 UCSF (Neurotree)
Herschel V. Wade post-doc 2000-2006 Penn
Kenichi Kuroda post-doc 2003-2006 University of Pennsylvania School of Medicine
Ting Xu post-doc 2006-2006 Penn
Hang Hubert Yin post-doc 2004-2007 UCSF
Gregory A. Caputo post-doc 2005-2007 Penn
Alessandro Senes post-doc 2004-2008 Penn
Bryan W. Berger post-doc 2006-2009 Penn (E-Tree)
Amanda J. Reig (Brooks) post-doc 2006-2009 Penn
Jonathan G. Rudick post-doc 2007-2010 Penn
Jun Wang post-doc 2011 UCSF
Ivan V. Korendovych post-doc 2006-2011 University of Pennsylvania School of Medicine
Gevorg Grigoryan post-doc 2008-2011 Penn
Brooke A. Rosenzweig post-doc 2010-2011
Mimi Cushman-Nick post-doc 2013-2016 UCSF (Neurotree)

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Publications

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Zhang MY, Yang H, Ortiz G, et al. (2022) Covalent labeling of a chromatin reader domain using proximity-reactive cyclic peptides. Chemical Science. 13: 6599-6609
Kratochvil HT, Newberry RW, Mensa B, et al. (2021) Spiers Memorial Lecture: Analysis and design of membrane-interactive peptides. Faraday Discussions
Thomaston JL, Samways ML, Konstantinidi A, et al. (2021) Rimantadine Binds to and Inhibits the Influenza A M2 Proton Channel without Enantiomeric Specificity. Biochemistry
Scott AJ, Niitsu A, Kratochvil HT, et al. (2021) Constructing ion channels from water-soluble α-helical barrels. Nature Chemistry
Naudin EA, McEwen AG, Tan SK, et al. (2021) Acyl Transfer Catalytic Activity in De Novo Designed Protein with N-Terminus of α-Helix As Oxyanion-Binding Site. Journal of the American Chemical Society
Boyce JH, Dang B, Ary B, et al. (2020) Platform to Discover Protease-Activated Antibiotics and Application to Siderophore-Antibiotic Conjugates. Journal of the American Chemical Society
Sundaram A, Chen C, Isik Reed N, et al. (2020) Dual antagonists of α5β1/ αvβ1 integrin for airway hyperresponsiveness. Bioorganic & Medicinal Chemistry Letters. 127578
Watkins LC, DeGrado WF, Voth GA. (2020) Influenza A M2 Inhibitor Binding Understood through Mechanisms of Excess Proton Stabilization and Channel Dynamics. Journal of the American Chemical Society. 142: 17425-17433
Polizzi NF, DeGrado WF. (2020) A defined structural unit enables de novo design of small-molecule-binding proteins. Science (New York, N.Y.). 369: 1227-1233
Newberry RW, Arhar T, Costello J, et al. (2020) Robust Sequence Determinants of α-Synuclein Toxicity in Yeast Implicate Membrane Binding. Acs Chemical Biology
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