Matthew Kyle Hadden
Affiliations: | University of Connecticut, Storrs, CT, United States |
Area:
Medicinal ChemistryGoogle:
"M. Kyle Hadden"Mean distance: (not calculated yet)
Parents
Sign in to add mentor| Thomas A. Dix | grad student | 2000-2004 | MUSC | |
| (Synthesis and evaluation of the antipsychotic potential of novel, orally bioavailable, NT(8--13) analogues containing non-natural arginine and lysine residues.) | ||||
| Brian Blagg | post-doc | |||
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Publications
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| Teske KA, Dash RC, Morel SR, et al. (2019) Development of posaconazole-based analogues as hedgehog signaling pathway inhibitors. European Journal of Medicinal Chemistry. 163: 320-332 |
| DeBerardinis AM, Banerjee U, Miller M, et al. (2012) Probing the structural requirements for vitamin D3 inhibition of the hedgehog signaling pathway. Bioorganic & Medicinal Chemistry Letters. 22: 4859-63 |
| Hadden MK, Blagg BS. (2009) Synthesis and evaluation of radamide analogues, a chimera of radicicol and geldanamycin. The Journal of Organic Chemistry. 74: 4697-704 |
| Orwig KS, Lassetter MR, Hadden MK, et al. (2009) Comparison of N-terminal modifications on neurotensin(8-13) analogues correlates peptide stability but not binding affinity with in vivo efficacy. Journal of Medicinal Chemistry. 52: 1803-13 |
| Hadden MK, Hill SA, Davenport J, et al. (2009) Synthesis and evaluation of Hsp90 inhibitors that contain the 1,4-naphthoquinone scaffold. Bioorganic & Medicinal Chemistry. 17: 634-40 |
| Hadden MK, Blagg BS. (2008) Dimeric approaches to anti-cancer chemotherapeutics. Anti-Cancer Agents in Medicinal Chemistry. 8: 807-16 |
| Tash JS, Chakrasali R, Jakkaraj SR, et al. (2008) Gamendazole, an orally active indazole carboxylic acid male contraceptive agent, targets HSP90AB1 (HSP90BETA) and EEF1A1 (eEF1A), and stimulates Il1a transcription in rat Sertoli cells. Biology of Reproduction. 78: 1139-52 |
| Hastings JM, Hadden MK, Blagg BS. (2008) Synthesis and evaluation of derrubone and select analogues. The Journal of Organic Chemistry. 73: 369-73 |
| Hadden MK, Galam L, Gestwicki JE, et al. (2007) Derrubone, an inhibitor of the Hsp90 protein folding machinery. Journal of Natural Products. 70: 2014-8 |
| Hadden MK, Blagg BS. (2007) Cytotoxic small molecule dimers and their inhibitory activity against human breast cancer cells. Bioorganic & Medicinal Chemistry Letters. 17: 5063-7 |