Kevin S. Orwig, Ph.D.
Affiliations: | 2006 | Medical University of South Carolina, Charleston, SC, United States |
Area:
PharmacologyGoogle:
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Sign in to add mentor| Thomas A. Dix | grad student | 2006 | MUSC | |
| (Evaluation of novel N -terminal capping groups in peptide -based drug design: A SAR study utilizing neurotensin (8 -13).) | ||||
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| Lundquist IV JT, Orwig KS, Dix TA. (2010) ChemInform Abstract: Synthesis of Ethylene-Bridged (Nδ to Nω) Analogues of Arginine. Cheminform. 31: no-no |
| Orwig KS, Lassetter MR, Hadden MK, et al. (2009) Comparison of N-terminal modifications on neurotensin(8-13) analogues correlates peptide stability but not binding affinity with in vivo efficacy. Journal of Medicinal Chemistry. 52: 1803-13 |
| Hadden MK, Orwig KS, Kokko KP, et al. (2005) Design, synthesis, and evaluation of the antipsychotic potential of orally bioavailable neurotensin (8-13) analogues containing non-natural arginine and lysine residues. Neuropharmacology. 49: 1149-59 |
| Kokko KP, Hadden MK, Price KL, et al. (2005) In vivo behavioral effects of stable, receptor-selective neurotensin[8-13] analogues that cross the blood-brain barrier. Neuropharmacology. 48: 417-25 |
| Orwig KS, Dix TA. (2005) Synthesis of Cα methylated carboxylic acids: isosteres of arginine and lysine for use as N-terminal capping residues in polypeptides Tetrahedron Letters. 46: 7007-7009 |
| Kokko KP, Hadden MK, Orwig KS, et al. (2003) In vitro analysis of stable, receptor-selective neurotensin[8-13] analogues. Journal of Medicinal Chemistry. 46: 4141-8 |
| Kennedy KJ, Orwig KS, Dix TA, et al. (2002) Synthesis and analysis of potent, more lipophilic derivatives of the bradykinin B2 receptor antagonist peptide Hoe 140. The Journal of Peptide Research : Official Journal of the American Peptide Society. 59: 139-48 |