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James K. Coward

Affiliations: 
1987-2007 Medicinal Chemistry University of Michigan, Ann Arbor, Ann Arbor, MI 
Area:
design potent and specific "mechanism-based inhibitors" of selected target enzymes for use as drugs in the treatment of cancer and parasitic diseases
Website:
https://www.lib.umich.edu/faculty-memoir/node/392
Google:
"James K. Coward"
Bio:

http://umich.edu/~jkclab/James%20K%20Coward.htm
http://um2017.org/faculty-history/faculty/james-k-coward-0
https://www.acsmedchem.org/?nd=Coward

Mean distance: 8.21
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Cross-listing: MichiganTree

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Parents

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Bernard Randall Baker grad student 1967 SUNY Buffalo
 (N-[3-pyrimidinyl)propyl]-sulfonamides and -carboxamides as inhibitors of dihydrofolic reductase and thymidylate synthetase)
Thomas C. Bruice post-doc 1969 UC Santa Barbara

Children

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Thomas B Johnson grad student 1980-1985 RPI
Robert J Miller grad student 1981-1985 RPI
Ruma Banerjee grad student 1982-1987 RPI
Eric K Yau grad student 1982-1987 RPI
Jung Lee grad student 1986-1991 University of Michigan
William P. Malachowski grad student 1987-1993 University of Michigan
Mark R Burns grad student 1988-1993 University of Michigan
Barry P Hart grad student 1988-1994 University of Michigan
John R Lakanen grad student 1988-1994 University of Michigan
Tong Xu grad student 1992-1997 University of Michigan
Matthew C. Hartman grad student 2002 University of Michigan
Hemant Khanna grad student 2002 University of Michigan
David W. Konas grad student 2002 University of Michigan
Matthew D. Alexander grad student 2004 University of Michigan
David M. Bartley grad student 2004 University of Michigan
Jessica J. Pankuch grad student 2004 University of Michigan
Anjali Srinivasan grad student 2004 University of Michigan
John W. Tomsho grad student 1998-2005 University of Michigan
Tara L. Hagena grad student 2008 University of Michigan
Patrick M. Woster post-doc 1986-1987 University of Michigan

Collaborators

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Publications

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Frantom PA, Coward JK, Blanchard JS. (2010) UDP-(5F)-GlcNAc acts as a slow-binding inhibitor of MshA, a retaining glycosyltransferase. Journal of the American Chemical Society. 132: 6626-7
Wang P, Wang Q, Yang Y, et al. (2010) Characterisation of the bifunctional dihydrofolate synthase-folylpolyglutamate synthase from Plasmodium falciparum; a potential novel target for antimalarial antifolate inhibition. Molecular and Biochemical Parasitology. 172: 41-51
McGuire JJ, Bartley DM, Tomsho JW, et al. (2010) Corrigendum to "Inhibition of human folylpolyglutamate synthetase by diastereomeric phosphinic acid mimics of the tetrahedral intermediate" [Archives of Biochemistry and Biophysics 488 (2009) 140-145] (DOI:10.1016/j.abb.2009.06.017) Archives of Biochemistry and Biophysics. 493: 250
MALACHOWSKI WP, COWARD JK. (2010) ChemInform Abstract: The Chemistry of Phosphapeptides: Investigations on the Synthesis of Phosphonamidate, Phosphonate, and Phosphinate Analogues of Glutamyl-. gamma.-glutamate. Cheminform. 26: no-no
HART BP, COWARD JK. (2010) ChemInform Abstract: The Synthesis of DL-3,3-Difluoroglutamic Acid (IX) from a 3- Oxoprolinol Derivative (I). Cheminform. 24: no-no
COWARD JK, MCGUIRE JJ, GALIVAN J. (2010) ChemInform Abstract: The Influence of Fluoro Substituents on the Reactivity of Carboxylic Acids, Amides, and Peptides in Enzyme-Catalyzed Reactions Cheminform. 22: no-no
McGuire JJ, Bartley DM, Tomsho JW, et al. (2009) Inhibition of human folylpolyglutamate synthetase by diastereomeric phosphinic acid mimics of the tetrahedral intermediate. Archives of Biochemistry and Biophysics. 488: 140-5
Majumdar D, Alexander MD, Coward JK. (2009) Synthesis of isopeptide epoxide peptidomimetics. The Journal of Organic Chemistry. 74: 617-27
Hagena TL, Coward JK. (2009) Fluoridolysis of 5,6-epoxy carbohydrates: application to the synthesis of 5-fluoro lactosamine and isolactosamine glycosides Tetrahedron Asymmetry. 20: 781-794
Oza SL, Chen S, Wyllie S, et al. (2008) ATP-dependent ligases in trypanothione biosynthesis--kinetics of catalysis and inhibition by phosphinic acid pseudopeptides. The Febs Journal. 275: 5408-21
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