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Rowena Green Matthews

Chemistry University of Michigan, Ann Arbor, Ann Arbor, MI 
Mechanisms of B12- and folate dependent enzymes
"Rowena Green Matthews"

Mean distance: 9.55
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George Wald research assistant 1965 Harvard
Vincent Massey grad student 1969 University of Michigan
 (Free and complexed forms of old yellow enzyme: their physical and catalytic properties)
Charles H. Williams post-doc University of Michigan
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Matthews RG. (2009) Cobalamin- and corrinoid-dependent enzymes. Metal Ions in Life Sciences. 6: 53-114
Koutmos M, Datta S, Pattridge KA, et al. (2009) Insights into the reactivation of cobalamin-dependent methionine synthase. Proceedings of the National Academy of Sciences of the United States of America. 106: 18527-32
Liptak MD, Fleischhacker AS, Matthews RG, et al. (2009) Spectroscopic and computational characterization of the base-off forms of cob(II)alamin. The Journal of Physical Chemistry. B. 113: 5245-54
Hondorp ER, Matthews RG. (2009) Oxidation of cysteine 645 of cobalamin-independent methionine synthase causes a methionine limitation in Escherichia coli. Journal of Bacteriology. 191: 3407-10
Matthews RG, Koutmos M, Datta S. (2008) Cobalamin-dependent and cobamide-dependent methyltransferases. Current Opinion in Structural Biology. 18: 658-66
Liptak MD, Datta S, Matthews RG, et al. (2008) Spectroscopic study of the cobalamin-dependent methionine synthase in the activation conformation: effects of the Y1139 residue and S-adenosylmethionine on the B12 cofactor. Journal of the American Chemical Society. 130: 16374-81
Datta S, Koutmos M, Pattridge KA, et al. (2008) A disulfide-stabilized conformer of methionine synthase reveals an unexpected role for the histidine ligand of the cobalamin cofactor. Proceedings of the National Academy of Sciences of the United States of America. 105: 4115-20
Koutmos M, Pejchal R, Bomer TM, et al. (2008) Metal active site elasticity linked to activation of homocysteine in methionine synthases. Proceedings of the National Academy of Sciences of the United States of America. 105: 3286-91
Matthews RG, Elmore CL. (2007) Defects in homocysteine metabolism: diversity among hyperhomocyst(e)inemias. Clinical Chemistry and Laboratory Medicine : Cclm / Fescc. 45: 1700-3
Fleischhacker AS, Matthews RG. (2007) Ligand trans influence governs conformation in cobalamin-dependent methionine synthase. Biochemistry. 46: 12382-92
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