Joshua R. Sacher, Ph.D.

Affiliations: 
2014- Stanley Center for Psychiatric Research Broad Institute of MIT and Harvard, USA 
Area:
chemistry, synthesis, organic chemistry, medicinal chemistry, neuroscience
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"Joshua Sacher"
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SNBCP

Parents

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Steven M. Weinreb grad student 2005-2012 Penn State
 (Progress toward a total synthesis of the Lycopodium alkaloid lycopladine h.)
Peter Wipf post-doc 2012-2014
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Publications

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Reidenbach AG, Mesleh MF, Casalena D, et al. (2020) Multimodal small-molecule screening for human prion protein binders. The Journal of Biological Chemistry
Hinze L, Labrosse R, Degar J, et al. (2020) Exploiting the Therapeutic Interaction of WNT Pathway Activation and Asparaginase for Colorectal Cancer Therapy. Cancer Discovery
Hinze L, Pfirrmann M, Karim S, et al. (2019) Synthetic Lethality of Wnt Pathway Activation and Asparaginase in Drug-Resistant Acute Leukemias. Cancer Cell. 35: 664-676.e7
Wagner FF, Benajiba L, Campbell AJ, et al. (2018) Exploiting an Asp-Glu "switch" in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia. Science Translational Medicine. 10
Weiwer M, Xu Q, Gale JP, et al. (2018) Functionally biased D2R antagonists: Targeting the β-arrestin pathway to improve antipsychotic treatment. Acs Chemical Biology
Epperly MW, Sacher JR, Krainz T, et al. (2017) Effectiveness of Analogs of the GS-Nitroxide, JP4-039, as Total Body Irradiation Mitigators. In Vivo (Athens, Greece). 31: 39-43
Krainz T, Gaschler MM, Lim C, et al. (2016) A Mitochondrial-Targeted Nitroxide Is a Potent Inhibitor of Ferroptosis. Acs Central Science. 2: 653-659
Wagner FF, Bishop JA, Gale JP, et al. (2016) Inhibitors of Glycogen Synthase Kinase 3 with Exquisite Kinome-wide Selectivity and their Functional Effects. Acs Chemical Biology
Ma J, Lim C, Sacher JR, et al. (2015) Mitochondrial targeted β-lapachone induces mitochondrial dysfunction and catastrophic vacuolization in cancer cells. Bioorganic & Medicinal Chemistry Letters
Chauhan PS, Sacher JR, Weinreb SM. (2015) Synthesis of the tetracyclic skeleton of the Lycopodium alkaloid lycopladine H via a pivotal double hydroformylation/intramolecular reductive amination sequence. Organic Letters. 17: 806-8
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