Christine A. Hrycyna, Ph.D.

2000- Chemistry Purdue University, West Lafayette, IN, United States 
multidrug resistance in human cancer
"Christine A. Hrycyna"

Mean distance: 8.87


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Steven G. Clarke grad student 1993 UCLA
 (The maturation of isoprenylated proteins in Saccharomyces cerevisiae)
Michael M. Gottesman post-doc 1993-2000 National Cancer Institute


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Aaron A Hoskins research assistant 1999-2000 Purdue (DevTree)
Jessica L. Kelts grad student 2000-2005 Purdue
Ndeye Khady Diop grad student 2006 Purdue
Karin Frida Ejendal grad student 2006 Purdue
Aarti Bhatia grad student 2007 Purdue
Amy Marie Griggs grad student 2009 Purdue
Sarah Elizabeth Hudon grad student 2009 Purdue
Dana Marie Emmert grad student 2011 Purdue
Kalub J. Hahne grad student 2012 Purdue
Brett M. Schilling grad student 2012 Purdue
Shengfeng Xu grad student 2012 Purdue
Amanda R. Logue grad student 2013 Purdue
Shiming Huang grad student 2014 Purdue
Kelsey Bohn grad student 2015 Purdue
Patricia Wiley grad student 2015 Purdue
Amy Funk grad student 2017 Purdue
Allison Lange grad student 2017 Purdue
Karen Olsen grad student 2017 Purdue
Erh-Ting Hsu grad student 2018 Purdue
Anna Ratliff grad student 2019 Purdue
Jason A. Goebel grad student 2014-2020 Purdue
Chelsea Theisen grad student 2021 Purdue


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Taysir K Bader collaborator 2018-2023 Purdue
BETA: Related publications


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Morstein J, Bader T, Cardillo AL, et al. (2022) Photoswitchable Isoprenoid Lipids Enable Optical Control of Peptide Lipidation. Acs Chemical Biology
Goebel J, Chmielewski J, Hrycyna CA. (2021) The roles of the human ATP-binding cassette transporters P-glycoprotein and ABCG2 in multidrug resistance in cancer and at endogenous sites: future opportunities for structure-based drug design of inhibitors. Cancer Drug Resistance (Alhambra, Calif.). 4: 784-804
Agrawal N, Rowe J, Lan J, et al. (2019) Potential tools for eradicating HIV reservoirs in the brain: the development of Trojan horse prodrugs for the inhibition of P-glycoprotein with anti-HIV-1 activity. Journal of Medicinal Chemistry
Wang C, Arrington J, Ratliff AC, et al. (2019) Methyltransferase-like 21c methylates and stabilizes the heat shock protein HSPA8 in type I myofibers in mice. The Journal of Biological Chemistry
Wang C, Zhang B, Ratliff AC, et al. (2019) Methyltransferase-like 21e inhibits 26S proteasome activity to facilitate hypertrophy of type IIb myofibers. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201900582R
Hsu ET, Vervacke JS, Distefano MD, et al. (2019) A Quantitative FRET Assay for the Upstream Cleavage Activity of the Integral Membrane Proteases Human ZMPSTE24 and Yeast Ste24. Methods in Molecular Biology (Clifton, N.J.). 2009: 279-293
Spear ED, Hsu ET, Nie L, et al. (2018) missense mutations that cause progeroid diseases decrease prelamin A cleavage activity and/or protein stability. Disease Models & Mechanisms
Diaz-Rodriguez V, Hsu ET, Ganusova E, et al. (2017) a-Factor Analogues Containing Alkyne- and Azide-Functionalized Isoprenoids Are Efficiently Enzymatically Processed and Retain Wild-Type Bioactivity. Bioconjugate Chemistry
Namanja-Magliano HA, Bohn K, Agrawal N, et al. (2017) Dual inhibitors of the human blood-brain barrier drug efflux transporters P-glycoprotein and ABCG2 based on the antiviral azidothymidine. Bioorganic & Medicinal Chemistry
Bohn K, Lange A, Chmielewski J, et al. (2017) Dual Modulation of Human P-glycoprotein and ABCG2 with Prodrug Dimers of the Atypical Antipsychotic Agent Paliperidone in a Model of the Blood-Brain Barrier. Molecular Pharmaceutics
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