Christine A. Hrycyna, Ph.D.

Affiliations:

2000-

Chemistry

Purdue University, West Lafayette, IN, United States

Area:

multidrug resistance in human cancer

Website:

https://www.chem.purdue.edu/hrycyna/

Google:

"Christine A. Hrycyna"

Bio:

http://www.chem.purdue.edu/hrycyna/about.html

Mean distance: 8.87

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Parents

Steven G. Clarke	grad student	1993	UCLA
(The maturation of isoprenylated proteins in Saccharomyces cerevisiae)
Michael M. Gottesman	post-doc	1993-2000	National Cancer Institute

Children

Aaron A Hoskins	research assistant	1999-2000	Purdue (DevTree)
Jessica L. Kelts	grad student	2000-2005	Purdue
Ndeye Khady Diop	grad student	2006	Purdue
Karin Frida Ejendal	grad student	2006	Purdue
Aarti Bhatia	grad student	2007	Purdue
Amy Marie Griggs	grad student	2009	Purdue
Sarah Elizabeth Hudon	grad student	2009	Purdue
Dana Marie Emmert	grad student	2011	Purdue
Kalub J. Hahne	grad student	2012	Purdue
Brett M. Schilling	grad student	2012	Purdue
Shengfeng Xu	grad student	2012	Purdue
Amanda R. Logue	grad student	2013	Purdue
Shiming Huang	grad student	2014	Purdue
Kelsey Bohn	grad student	2015	Purdue
Patricia Wiley	grad student	2015	Purdue
Amy Funk	grad student	2017	Purdue
Allison Lange	grad student	2017	Purdue
Karen Olsen	grad student	2017	Purdue
Erh-Ting Hsu	grad student	2018	Purdue
Anna Ratliff	grad student	2019	Purdue
Jason A. Goebel	grad student	2014-2020	Purdue
Chelsea Theisen	grad student	2021	Purdue

Collaborators

Taysir K Bader

collaborator

2018-2023

Purdue

BETA: Related publications

Publications

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Morstein J, Bader T, Cardillo AL, et al. (2022) Photoswitchable Isoprenoid Lipids Enable Optical Control of Peptide Lipidation. Acs Chemical Biology
Goebel J, Chmielewski J, Hrycyna CA. (2021) The roles of the human ATP-binding cassette transporters P-glycoprotein and ABCG2 in multidrug resistance in cancer and at endogenous sites: future opportunities for structure-based drug design of inhibitors. Cancer Drug Resistance (Alhambra, Calif.). 4: 784-804
Agrawal N, Rowe J, Lan J, et al. (2019) Potential tools for eradicating HIV reservoirs in the brain: the development of Trojan horse prodrugs for the inhibition of P-glycoprotein with anti-HIV-1 activity. Journal of Medicinal Chemistry
Wang C, Arrington J, Ratliff AC, et al. (2019) Methyltransferase-like 21c methylates and stabilizes the heat shock protein HSPA8 in type I myofibers in mice. The Journal of Biological Chemistry
Wang C, Zhang B, Ratliff AC, et al. (2019) Methyltransferase-like 21e inhibits 26S proteasome activity to facilitate hypertrophy of type IIb myofibers. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201900582R
Hsu ET, Vervacke JS, Distefano MD, et al. (2019) A Quantitative FRET Assay for the Upstream Cleavage Activity of the Integral Membrane Proteases Human ZMPSTE24 and Yeast Ste24. Methods in Molecular Biology (Clifton, N.J.). 2009: 279-293
Spear ED, Hsu ET, Nie L, et al. (2018) missense mutations that cause progeroid diseases decrease prelamin A cleavage activity and/or protein stability. Disease Models & Mechanisms
Diaz-Rodriguez V, Hsu ET, Ganusova E, et al. (2017) a-Factor Analogues Containing Alkyne- and Azide-Functionalized Isoprenoids Are Efficiently Enzymatically Processed and Retain Wild-Type Bioactivity. Bioconjugate Chemistry
Namanja-Magliano HA, Bohn K, Agrawal N, et al. (2017) Dual inhibitors of the human blood-brain barrier drug efflux transporters P-glycoprotein and ABCG2 based on the antiviral azidothymidine. Bioorganic & Medicinal Chemistry
Bohn K, Lange A, Chmielewski J, et al. (2017) Dual Modulation of Human P-glycoprotein and ABCG2 with Prodrug Dimers of the Atypical Antipsychotic Agent Paliperidone in a Model of the Blood-Brain Barrier. Molecular Pharmaceutics