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Thomas L. Nowak

Affiliations: 
Chemistry and Biochemistry University of Notre Dame, Notre Dame, IN, United States 
Area:
enzyme mechanisms, their regulation and structure and how they are interrelated
Website:
http://chemistry.nd.edu/faculty/detail/tnowak/
Google:
"Thomas L. Nowak"
Bio:

http://science.nd.edu/news/34587-enzyme-mini-symposium-to-celebrate-the-career-of-thomas-nowak/
http://chemistry.library.nd.edu/resources/genealogy/chemistry/documents/NowakTL.pdf

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Parents

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Richard Howard Himes grad student 1969 University of Kansas
 (Role of the sulfhydryl groups in formyltetrahydrofolate synthetase)
Albert S. Mildvan post-doc 1972 Fox Chase Cancer Center

Children

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Andrew D. Mesecar grad student 1995 Notre Dame
J. Patrick Loria grad student 1997 Notre Dame
Todd Holyoak grad student 2000 Notre Dame
Sandra E. Rios grad student 2000 Notre Dame
Delia I. Susan-Resiga grad student 2003 Notre Dame

Collaborators

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Publications

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Holyoak T, Sullivan SM, Nowak T. (2006) Structural insights into the mechanism of PEPCK catalysis. Biochemistry. 45: 8254-63
Susan-Resiga D, Nowak T. (2004) Proton donor in yeast pyruvate kinase: chemical and kinetic properties of the active site Thr 298 to Cys mutant. Biochemistry. 43: 15230-15245
Holyoak T, Nowak T. (2004) pH Dependence of the reaction catalyzed by avian mitochondrial phosphoenolpyruvate carboxykinase. Biochemistry. 43: 7054-65
Susan-Resiga D, Nowak T. (2003) Monitoring active site alterations upon mutation of yeast pyruvate kinase using 205Tl+ NMR Journal of Biological Chemistry. 278: 40943-40952
Susan-Resiga D, Nowak T. (2003) The proton transfer step catalyzed by yeast pyruvate kinase. Journal of Biological Chemistry. 278: 12660-12671
Krautwurst H, Roschzttardtz H, Bazaes S, et al. (2002) Lysine 213 and histidine 233 participate in Mn(II) binding and catalysis in Saccharomyces cerevisiae phosphoenolpyruvate carboxykinase. Biochemistry. 41: 12763-70
Ríos SE, Nowak T. (2002) Role of cysteine 306 in the catalytic mechanism of Ascaris suum phosphoenolpyruvate carboxykinase. Archives of Biochemistry and Biophysics. 404: 25-37
Bollenbach TJ, Nowak T. (2001) Kinetic Linked-Function Analysis of the Multiligand Interactions on Mg2+-Activated Yeast Pyruvate Kinase† Biochemistry. 40: 13097-13106
Bollenbach TJ, Nowak T. (2001) Thermodynamic Linked-Function Analysis of Mg2+-Activated Yeast Pyruvate Kinase† Biochemistry. 40: 13088-13096
Holyoak T, Nowak T. (2001) Structural investigation of the binding of nucleotide to phosphoenolpyruvate carboxykinase by NMR. Biochemistry. 40: 11037-47
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