Kyle Landgraf

Affiliations: 
Genentech, Inc., San Francisco, CA, United States 
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"Kyle Landgraf"
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Joseph J. Falke grad student 2009 CU Boulder
 (Second messenger regulated membrane targeting: Membrane docking mechanisms of C2 and PH domains.)
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Publications

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Ziemba BP, Li J, Landgraf KE, et al. (2014) Single-molecule studies reveal a hidden key step in the activation mechanism of membrane-bound protein kinase C-α. Biochemistry. 53: 1697-713
Chen HC, Ziemba BP, Landgraf KE, et al. (2012) Membrane docking geometry of GRP1 PH domain bound to a target lipid bilayer: an EPR site-directed spin-labeling and relaxation study. Plos One. 7: e33640
Pilling C, Landgraf KE, Falke JJ. (2011) The GRP1 PH domain, like the AKT1 PH domain, possesses a sentry glutamate residue essential for specific targeting to plasma membrane PI(3,4,5)P(3). Biochemistry. 50: 9845-56
Lai CL, Landgraf KE, Voth GA, et al. (2010) Membrane docking geometry and target lipid stoichiometry of membrane-bound PKCα C2 domain: a combined molecular dynamics and experimental study. Journal of Molecular Biology. 402: 301-10
Hutchinson MR, Loram LC, Zhang Y, et al. (2010) Evidence that tricyclic small molecules may possess toll-like receptor and myeloid differentiation protein 2 activity. Neuroscience. 168: 551-63
Hutchinson MR, Zhang Y, Shridhar M, et al. (2010) Evidence that opioids may have toll-like receptor 4 and MD-2 effects. Brain, Behavior, and Immunity. 24: 83-95
Owens ZJ, Landgraf KE, Corbin JA, et al. (2010) Structural Analysis of the Membrane Docking Geometry of PI(3,4,5)P3-Specific GRP1-PH Domain Via Site-Directed Spin Labeling Biophysical Journal. 98: 400a-401a
Landgraf KE, Pilling C, Falke JJ. (2008) Molecular mechanism of an oncogenic mutation that alters membrane targeting: Glu17Lys modifies the PIP lipid specificity of the AKT1 PH domain. Biochemistry. 47: 12260-9
Landgraf KE, Malmberg NJ, Falke JJ. (2008) Effect of PIP2 binding on the membrane docking geometry of PKC alpha C2 domain: an EPR site-directed spin-labeling and relaxation study. Biochemistry. 47: 8301-16
Corbin JA, Evans JH, Landgraf KE, et al. (2007) Mechanism of specific membrane targeting by C2 domains: localized pools of target lipids enhance Ca2+ affinity. Biochemistry. 46: 4322-36
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