Thomas H. Graham

Affiliations: 
Merck Research Laboratories - Boston, Boston, MA 
Area:
Medicinal Chemistry
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Parents

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Peter Wipf grad student 2000-2006 University of Pittsburgh
 (The synthesis of oxazole-containing natural products.)
David W.C. MacMillan post-doc 2006-2008 Princeton
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Publications

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McLaren DG, Han S, Murphy BA, et al. (2018) DGAT2 Inhibition Alters Aspects of Triglyceride Metabolism in Rodents but Not in Non-human Primates. Cell Metabolism
Graham TH. (2017) Prolylcarboxypeptidase (PrCP) inhibitors and the therapeutic uses thereof: a patent review. Expert Opinion On Therapeutic Patents. 1-12
Graham TH. (2015) Deprotection of N-benzylbenzimidazoles and N-benzylimidazoles with triethylsilane and Pd/C Tetrahedron Letters. 56: 2688-2690
Graham TH, Shu M, Verras A, et al. (2014) Pyrazoles as non-classical bioisosteres in prolylcarboxypeptidase (PrCP) inhibitors. Bioorganic & Medicinal Chemistry Letters. 24: 1657-60
Debenham JS, Graham TH, Verras A, et al. (2013) Discovery and optimization of orally active cyclohexane-based prolylcarboxypeptidase (PrCP) inhibitors. Bioorganic & Medicinal Chemistry Letters. 23: 6228-33
Shen HC, Graham TH. (2013) Gold-catalyzed formation of heterocycles - an enabling new technology for medicinal chemistry. Drug Discovery Today. Technologies. 10: e3-14
Graham TH, Liu W, Verras A, et al. (2012) A new class of prolylcarboxypeptidase inhibitors, part 2: the aminocyclopentanes. Bioorganic & Medicinal Chemistry Letters. 22: 2818-22
Graham TH, Liu W, Verras A, et al. (2012) A new class of prolylcarboxypeptidase inhibitors, part 1: discovery and evaluation. Bioorganic & Medicinal Chemistry Letters. 22: 2811-7
Wu Z, Yang C, Graham TH, et al. (2012) Discovery of aminoheterocycles as potent and brain penetrant prolylcarboxypeptidase inhibitors. Bioorganic & Medicinal Chemistry Letters. 22: 1727-30
Graham TH, Shen HC, Liu W, et al. (2012) The discovery of non-benzimidazole and brain-penetrant prolylcarboxypeptidase inhibitors. Bioorganic & Medicinal Chemistry Letters. 22: 658-65
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