K. G. Rajeev

1997 CSIR-National Chemical Laboratory, Pune, India 
"K. Rajeev"
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Parmar R, Willoughby JL, Liu J, et al. (2016) 5'-(E)-Vinylphosphonate: A Stable Phosphate Mimic Can Improve the RNAi Activity of siRNA-GalNAc Conjugates. Chembiochem : a European Journal of Chemical Biology
Butler JS, Chan A, Costelha S, et al. (2016) Preclinical evaluation of RNAi as a treatment for transthyretin-mediated amyloidosis. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 1-10
Kel In AV, Zlatev I, Harp J, et al. (2016) Structural Basis of Duplex Thermodynamic Stability and Enhanced Nuclease Resistance of 5'-C-Methyl Pyrimidine-Modified Oligonucleotides. The Journal of Organic Chemistry
Zlatev I, Foster DJ, Liu J, et al. (2015) 5'-C-Malonyl RNA: small interfering RNAs modified with 5'-monophosphate bioisostere demonstrate gene silencing activity. Acs Chemical Biology
Sehgal A, Barros S, Ivanciu L, et al. (2015) An RNAi therapeutic targeting antithrombin to rebalance the coagulation system and promote hemostasis in hemophilia. Nature Medicine. 21: 492-7
Rajeev KG, Nair JK, Jayaraman M, et al. (2015) Hepatocyte-specific delivery of siRNAs conjugated to novel non-nucleosidic trivalent N-acetylgalactosamine elicits robust gene silencing in vivo. Chembiochem : a European Journal of Chemical Biology. 16: 903-8
Matsuda S, Keiser K, Nair JK, et al. (2015) siRNA conjugates carrying sequentially assembled trivalent N-acetylgalactosamine linked through nucleosides elicit robust gene silencing in vivo in hepatocytes. Acs Chemical Biology. 10: 1181-7
Nair JK, Willoughby JL, Chan A, et al. (2014) Multivalent N-acetylgalactosamine-conjugated siRNA localizes in hepatocytes and elicits robust RNAi-mediated gene silencing. Journal of the American Chemical Society. 136: 16958-61
Hu J, Liu J, Narayanannair KJ, et al. (2014) Allele-selective inhibition of mutant atrophin-1 expression by duplex and single-stranded RNAs. Biochemistry. 53: 4510-8
Liu J, Pendergraff H, Narayanannair KJ, et al. (2013) RNA duplexes with abasic substitutions are potent and allele-selective inhibitors of huntingtin and ataxin-3 expression. Nucleic Acids Research. 41: 8788-801
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