Thomas R. Caulfield, Ph.D.

Affiliations: 
2008 Georgia Institute of Technology, Atlanta, GA 
Area:
General Biophysics, Biochemistry, Molecular Biology
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"Thomas Caulfield"
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Stephen C. Harvey grad student 2008 Georgia Tech
 (Structural basis for the fidelity of translation: Modeling the accommodation pathway.)
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Publications

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Abdul-Hay SO, Bannister TD, Wang H, et al. (2015) Selective targeting of extracellular insulin-degrading enzyme by quasi-irreversible thiol-modifying inhibitors. Acs Chemical Biology
Fiesel FC, Ando M, Hudec R, et al. (2015) (Patho-)physiological relevance of PINK1-dependent ubiquitin phosphorylation. Embo Reports
Fiesel FC, Caulfield TR, Moussaud-Lamodière EL, et al. (2015) Structural and Functional Impact of Parkinson Disease-Associated Mutations in the E3 Ubiquitin Ligase Parkin. Human Mutation. 36: 774-86
Caulfield TR, Fiesel FC, Springer W. (2015) Activation of the E3 ubiquitin ligase Parkin. Biochemical Society Transactions. 43: 269-74
Chitta K, Paulus A, Akhtar S, et al. (2015) Targeted inhibition of the deubiquitinating enzymes, USP14 and UCHL5, induces proteotoxic stress and apoptosis in Waldenström macroglobulinaemia tumour cells. British Journal of Haematology. 169: 377-90
Caulfield TR, Fiesel FC, Moussaud-Lamodière EL, et al. (2014) Phosphorylation by PINK1 releases the UBL domain and initializes the conformational opening of the E3 ubiquitin ligase Parkin. Plos Computational Biology. 10: e1003935
Lee WC, Almeida S, Prudencio M, et al. (2014) Targeted manipulation of the sortilin-progranulin axis rescues progranulin haploinsufficiency. Human Molecular Genetics. 23: 1467-78
von Roemeling CA, Marlow LA, Wei JJ, et al. (2013) Stearoyl-CoA desaturase 1 is a novel molecular therapeutic target for clear cell renal cell carcinoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 19: 2368-80
Abdul-Hay SO, Lane AL, Caulfield TR, et al. (2013) Optimization of peptide hydroxamate inhibitors of insulin-degrading enzyme reveals marked substrate-selectivity. Journal of Medicinal Chemistry. 56: 2246-55
Batra J, Szabó A, Caulfield TR, et al. (2013) Long-range electrostatic complementarity governs substrate recognition by human chymotrypsin C, a key regulator of digestive enzyme activation. The Journal of Biological Chemistry. 288: 9848-59
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