Ari M.P. Koskinen, Ph.D.

Affiliations: 
Chemistry Aalto University, Espoo, Finland 
Area:
organic synthesis, natural products, chemical biology
Website:
http://users.aalto.fi/akoskine/
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"Ari Koskinen"
Bio:

Professor Ari M.P.Koskinen was born on September 22, 1956 in Finland. He received his M.Sc. (Chem. Eng.) in 1979 (with professor T. Hase, development of the synthesis of alkyl tert -alkyl ethers for anti-knock agents), Licentiate in Technology in 1982 and Doctor of Technology in 1983 (with professor M. Lounasmaa, methodology development on the modified Polonovski reaction for indole alkaloid synthesis), all at the Helsinki University of Technology, Finland. After postdoctoral studies at the University of California, Berkeley (professor Henry Rapoport 1983-85 and 1987-88, total synthesis of anatoxin-a, and conformationally constrained peptidomimetics) he accepted an appointment as a Project Leader in New Drug Development at Orion Corporation - Fermion, Finland (1985-1987). His research group was among the first in Scandinavia to adopt computer aided drug design (QSAR and CoMFA) as well as computerized database handling protocols in new lead identification. Returning to the Academia, he joined the University of Surrey, England, as a lecturer in 1989. He was then appointed as Professor of Chemistry (especially Synthetic Organic Chemistry) at the University of Oulu, Finland in 1992, and transferred to his current position at the Helsinki University of Technology in August, 1999 as Professor of Organic Chemistry (the old Gustav Komppa chair). He also holds docentships at the Universities of Helsinki and Turku, Finland. Prof. Koskinen is a member of the Finnish Academy of Sciences and Letters since 2003, and member of the Novartis Foundation International Scientific Advisory Panel since 2004. (Source: Professor Ari M.P.Koskinen was born on September 22, 1956 in Finland. He received his M.Sc. (Chem. Eng.) in 1979 (with professor T. Hase, development of the synthesis of alkyl tert -alkyl ethers for anti-knock agents), Licentiate in Technology in 1982 and Doctor of Technology in 1983 (with professor M. Lounasmaa, methodology development on the modified Polonovski reaction for indole alkaloid synthesis), all at the Helsinki University of Technology, Finland. After postdoctoral studies at the University of California, Berkeley (professor Henry Rapoport 1983-85 and 1987-88, total synthesis of anatoxin-a, and conformationally constrained peptidomimetics) he accepted an appointment as a Project Leader in New Drug Development at Orion Corporation - Fermion, Finland (1985-1987). His research group was among the first in Scandinavia to adopt computer aided drug design (QSAR and CoMFA) as well as computerized database handling protocols in new lead identification. Returning to the Academia, he joined the University of Surrey, England, as a lecturer in 1989. He was then appointed as Professor of Chemistry (especially Synthetic Organic Chemistry) at the University of Oulu, Finland in 1992, and transferred to his current position at the Helsinki University of Technology in August, 1999 as Professor of Organic Chemistry (the old Gustav Komppa chair). He also holds docentships at the Universities of Helsinki and Turku, Finland. Prof. Koskinen is a member of the Finnish Academy of Sciences and Letters since 2003, and member of the Novartis Foundation International Scientific Advisory Panel since 2004. (Source: http://users.tkk.fi/akoskine/amk_main.htm)
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Parents

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Tapio A. Hase research assistant 1978-1979 Helsinki University of Technology
Mauri Lounasmaa grad student 1981-1983 Helsinki University of Technology
Henry Rapoport post-doc 1983-1985 UC Berkeley
 (also 1987-1988)
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Publications

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Konstantinova OV, Koskinen AMP. (2019) Synthesis of the C1-C12 Fragment of Calyculin C Synthesis. 51: 285-295
Van Adrichem AJ, Fagerholm A, Turunen L, et al. (2015) Discovery of MINC1, a GTPase-activating protein small molecule inhibitor, targeting MgcRacGAP Combinatorial Chemistry and High Throughput Screening. 18: 3-17
Rembiak A, Koskinen AMP. (2015) Versatile Synthesis of Symmetrical Carbazole Based Ligand Precursors via Regioselective Aromatic Bromination Synthesis. 47: 3347-3353
Sundqvist T, Oasmaa A, Koskinen A. (2015) Upgrading fast pyrolysis bio-oil quality by esterification and azeotropic water removal Energy and Fuels. 29: 2527-2534
Lood CS, Nieger M, Koskinen AMP. (2015) Enantiospecific gram scale synthesis of (S)-eleagnine Tetrahedron. 71: 5019-5024
Lood CS, Laine AE, Högnäsbacka A, et al. (2015) Synthesis of chiral (indol-2-yl)methanamines and insight into the stereochemistry protecting effects of the 9-phenyl-9-fluorenyl protecting group European Journal of Organic Chemistry. 2015: 3793-3805
Ihanainen NE, Kumpulainen ETT, Koskinen AMP. (2015) Palladium-catalyzed direct C-H arylation of dicyanobenzenes European Journal of Organic Chemistry. 2015: 3226-3229
Koskinen AMP, Kataja AO. (2015) The Tishchenko Reaction Organic Reactions. 105-410
Huy PH, Westphal JC, Koskinen AM. (2014) Concise, stereodivergent and highly stereoselective synthesis of cis- and trans-2-substituted 3-hydroxypiperidines - development of a phosphite-driven cyclodehydration. Beilstein Journal of Organic Chemistry. 10: 369-83
Laine AE, Lood C, Koskinen AM. (2014) Pharmacological importance of optically active tetrahydro-β-carbolines and synthetic approaches to create the C1 stereocenter. Molecules (Basel, Switzerland). 19: 1544-67
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