Humayun Sharif, Ph.D.
Affiliations: | Biological Chemistry and Molecular Pharmacology | Harvard Medical School, Boston, MA, United States |
Area:
Xray Crystalllography, Structural biology, Cancer Biology, Cell Signaling, Protein Protein InterationGoogle:
"Humayun Sharif"Mean distance: 8.89 | S | N | B | C | P |
Parents
Sign in to add mentor| Soo Hyun Eom | grad student | 2008-2010 | Gwangju Institute of Science and Technology | |
| (Master's thesis: Structural and functional analysis of FtsH periplasmic domain) | ||||
| Elena Conti | grad student | 2010-2014 | Max Planck Institute of Biochemistry, Martinsried | |
| (Structural and biochemical characterization of eukaryotic mRNA decapping activators) | ||||
| Hao Wu | post-doc | 2016- | Harvard Medical School - Boston Children's Hospital | |
| Michael J. Eck | post-doc | 2014-2015 | Harvard Medical School/Dana-Farber Cancer Institute | |
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Publications
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| Wang L, Sharif H, Vora SM, et al. (2021) Structures and functions of the inflammasome engine. The Journal of Allergy and Clinical Immunology. 147: 2021-2029 |
| Sharif H, Hollingsworth LR, Griswold AR, et al. (2021) Dipeptidyl peptidase 9 sets a threshold for CARD8 inflammasome formation by sequestering its active C-terminal fragment. Immunity |
| Hollingsworth LR, Sharif H, Griswold AR, et al. (2021) DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation. Nature |
| Robert Hollingsworth L, David L, Li Y, et al. (2021) Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes. Nature Communications. 12: 189 |
| Magupalli VG, Negro R, Tian Y, et al. (2020) HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation. Science (New York, N.Y.). 369 |
| Park E, Rawson S, Li K, et al. (2019) Architecture of autoinhibited and active BRAF-MEK1-14-3-3 complexes. Nature |
| Sharif H, Wang L, Wang WL, et al. (2019) Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome. Nature |
| Shen C, Sharif H, Xia S, et al. (2019) Structural and mechanistic elucidation of inflammasome signaling by cryo-EM. Current Opinion in Structural Biology. 58: 18-25 |
| An JY, Sharif H, Kang GB, et al. (2018) Structural insights into the oligomerization of FtsH periplasmic domain from Thermotoga maritima. Biochemical and Biophysical Research Communications. 495: 1201-1207 |
| Sharif H, Li Y, Dong Y, et al. (2017) Cryo-EM structure of the DNA-PK holoenzyme. Proceedings of the National Academy of Sciences of the United States of America |