Humayun Sharif, Ph.D.

Biological Chemistry and Molecular Pharmacology Harvard Medical School, Boston, MA, United States 
Xray Crystalllography, Structural biology, Cancer Biology, Cell Signaling, Protein Protein Interation
"Humayun Sharif"
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Soo Hyun Eom grad student 2008-2010 Gwangju Institute of Science and Technology
 (Master's thesis: Structural and functional analysis of FtsH periplasmic domain)
Elena Conti grad student 2010-2014 Max Planck Institute of Biochemistry, Martinsried
 (Structural and biochemical characterization of eukaryotic mRNA decapping activators)
Hao Wu post-doc 2016- Harvard Medical School - Boston Children's Hospital
Michael J. Eck post-doc 2014-2015 Harvard Medical School/Dana-Farber Cancer Institute
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Wang L, Sharif H, Vora SM, et al. (2021) Structures and functions of the inflammasome engine. The Journal of Allergy and Clinical Immunology. 147: 2021-2029
Sharif H, Hollingsworth LR, Griswold AR, et al. (2021) Dipeptidyl peptidase 9 sets a threshold for CARD8 inflammasome formation by sequestering its active C-terminal fragment. Immunity
Hollingsworth LR, Sharif H, Griswold AR, et al. (2021) DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation. Nature
Robert Hollingsworth L, David L, Li Y, et al. (2021) Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes. Nature Communications. 12: 189
Magupalli VG, Negro R, Tian Y, et al. (2020) HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation. Science (New York, N.Y.). 369
Park E, Rawson S, Li K, et al. (2019) Architecture of autoinhibited and active BRAF-MEK1-14-3-3 complexes. Nature
Sharif H, Wang L, Wang WL, et al. (2019) Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome. Nature
Shen C, Sharif H, Xia S, et al. (2019) Structural and mechanistic elucidation of inflammasome signaling by cryo-EM. Current Opinion in Structural Biology. 58: 18-25
An JY, Sharif H, Kang GB, et al. (2018) Structural insights into the oligomerization of FtsH periplasmic domain from Thermotoga maritima. Biochemical and Biophysical Research Communications. 495: 1201-1207
Sharif H, Li Y, Dong Y, et al. (2017) Cryo-EM structure of the DNA-PK holoenzyme. Proceedings of the National Academy of Sciences of the United States of America
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