Leslie Hough

Affiliations: 
Chemistry King's College London, London, UK 
Area:
carbohydrate chemistry
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"Leslie Hough"
Bio:

Leslie Hough was born in 1925 in Lancashire. He graduated in 1946 from the University of Manchester with an Honors degree in Chemistry. He commenced research on carbohydrates with Professor (later Sir Edmund) E. L. Hirst and Dr. (later Professor) J.K.N. Jones, took the M.Sc. in 1947 and completed his Ph.D. in 1949. Collaboration with Jones continued when Dr. Hough joined the academic staff at the University of Bristol in 1950. As a Fulbright Scholar he took sabbatical leave in 1952 to study at Purdue University with Professor Roy L. Whistler. When J.K.N. Jones became the Chown Research Professor at Queens University, Ontario, in 1954, Dr. Hough directed the carbohydrate research at Bristol on glycoproteins, carbon-14 tracer studies and the interplay between conformation and reactivity. Research on sucrose commenced in 1956 with the support of the International Sugar Research Foundation (now W.R.S.O.) and continued with Tate and Lyle.
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Machinami T, Iibuchi N, Nomura T, et al. (2002) Synthesis of aminoacyl sugar derivatives and their taste characteristics. I. 2,3-Di-O-aminoacyl derivatives of alkyl D-glucopyranosides Journal of Carbohydrate Chemistry. 21: 131-142
Machinami T, Fujimoto T, Takatsuka A, et al. (2002) Design and synthesis of new sweeteners Pure and Applied Chemistry. 74: 1219-1225
Suami T, Hough L, Machinami T, et al. (1998) Molecular mechanisms of sweet taste 8*: Saccharin, acesulfame-K, cyclamate and their derivatives Food Chemistry. 63: 391-396
Suami T, Hough L, Machinami T, et al. (1997) Molecular mechanisms of sweet taste 7: The sweet protein, Thaumatin I Food Chemistry. 60: 277-285
Hough L, Suami T, Machinami T. (1997) Manipulation and magnification of the sweetness of sucrose Pure and Applied Chemistry. 69: 693-699
Suami T, Hough L, Machinami T, et al. (1996) Molecular mechanisms of sweet taste. Part 6 *: The sweet protein, Monellin Food Chemistry. 56: 275-281
Suami T, Hough L. (1993) Molecular mechanisms of sweet taste: IV. Sucrononic acid and a related derivative Food Chemistry. 48: 267-268,IN1-IN2,269-
Suami T, Hough L. (1993) Molecular mechanisms of sweet taste 3: aspartame and its non-sweet isomers Food Chemistry. 46: 235-238
Ali MA, Hough L, Richardson AC. (1992) Thio and epidithio derivatives of methyl β-lactoside Carbohydrate Research. 216: 271-287
Suami T, Hough L. (1991) Molecular mechanisms of sweet taste 1: Sweet and non-sweet tasting amino acids Journal of Carbohydrate Chemistry. 10: 851-860
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