Richard Novick, M.D.

Affiliations:

Microbiology

New York University, New York, NY, United States

Area:

Staphylococcus aureus; superantigens; mobile genes; pathogenicity islands, signal transduction, regulation of virulence, microbial pathogenesis; MRSA; bacterial genetics

Website:

http://microbiology-parasitology.med.nyu.edu/richard-novick

Google:

"Richard Novick"

Bio:

http://www.nasonline.org/member-directory/members/20012496.html
http://skirball.med.nyu.edu/faculty/richard-p-novick/novick-lab
http://www.med.nyu.edu/biosketch/novicr01
http://dx.doi.org/10.1073/pnas.0707438104
RESEARCH INTERESTS: Our lab is focused on the study of staphylococcal virulence, its genetic and regulation. There are two major areas:

1. Global regulation of virulence genes by agr. Virulence in S. aureus is regulated by a complex network of regulatory determinants, the most important of which is the agr locus, which we have identified and characterized. The agr locus contains a two-component signaling module that is autoinduced by a small semi-cyclic peptide (AIP), that is encoded within the locus, is secreted, and then binds to AgrC, the signal receptor, activating the system. agr operates by autoinduction and is therefore a quorum sensor.

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Mean distance: 8.92

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