Mallinath B. Hadimani, Ph.D.

2004 Baylor University, Waco, TX 
Organic Chemistry
"Mallinath Hadimani"
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Kevin George Pinney grad student 2004 Baylor University
 (Studies toward the discovery of new classes of privileged molecules as colchicine-site binding ligands for tubulin: Structure-based design, synthesis and bioactivity of small ligands targeted at tumor vasculature.)
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Hadimani MB, Mukherjee R, Banerjee R, et al. (2015) Ring expansions of acyloxy nitroso compounds. Tetrahedron Letters. 56: 5870-5873
Strecker TE, Odutola SO, Lopez R, et al. (2015) The vascular disrupting activity of OXi8006 in endothelial cells and its phosphate prodrug OXi8007 in breast tumor xenografts. Cancer Letters. 369: 229-41
Hadimani MB, Macdonough MT, Ghatak A, et al. (2013) Synthesis of a 2-aryl-3-aroyl indole salt (OXi8007) resembling combretastatin A-4 with application as a vascular disrupting agent. Journal of Natural Products. 76: 1668-78
Shirali A, Sriram M, Hall JJ, et al. (2009) Development of synthetic methodology suitable for the radiosynthesis of combretastatin A-1 (CA1) and its corresponding prodrug CA1P. Journal of Natural Products. 72: 414-21
Hall JJ, Sriram M, Strecker TE, et al. (2008) Design, synthesis, biochemical, and biological evaluation of nitrogen-containing trifluoro structural modifications of combretastatin A-4. Bioorganic & Medicinal Chemistry Letters. 18: 5146-9
Siles R, Ackley JF, Hadimani MB, et al. (2008) Combretastatin dinitrogen-substituted stilbene analogues as tubulin-binding and vascular-disrupting agents. Journal of Natural Products. 71: 313-20
Monk KA, Siles R, Hadimani MB, et al. (2006) Design, synthesis, and biological evaluation of combretastatin nitrogen-containing derivatives as inhibitors of tubulin assembly and vascular disrupting agents. Bioorganic & Medicinal Chemistry. 14: 3231-44
Hadimani MB, Hua J, Jonklaas MD, et al. (2003) Synthesis, in vitro, and in vivo evaluation of phosphate ester derivatives of combretastatin A-4. Bioorganic & Medicinal Chemistry Letters. 13: 1505-8
Hadimani MB, Kessler RJ, Kautz JA, et al. (2002) 2-(3-tert-Butyldimethylsiloxy-4-methoxyphenyl)-6-methoxy-3-(3,4,5-trimethoxybenzoyl)indole. Acta Crystallographica. Section C, Crystal Structure Communications. 58: o330-2
Hadimani MB, Kessler RJ, Kautz JA, et al. (2002) 2-(3-tert-butyldimethylsiloxy-4-methoxyphenyl)-6-methoxy-3-(3,4, 5-trimethoxybenzoyl)indole Acta Crystallographica Section C: Crystal Structure Communications. 58: o330-o332
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