Xin Linghu, Ph.D.
Affiliations: | Chemistry | Genentech, Inc., San Francisco, CA, United States |
Area:
organic chemistryGoogle:
"Xin Linghu"Mean distance: 7.4 | S | N | B | C | P |
Parents
Sign in to add mentor| Jeffrey S. Johnson | grad student | 2000-2005 | UNC Chapel Hill |
| F. Dean Toste | post-doc | UC Berkeley |
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Publications
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| Molinaro C, Kelly S, Tang A, et al. (2023) Asymmetric Synthesis of -Alkyl Amino Acids through a Biocatalytic Dynamic Kinetic Resolution of PEGylated -Alkyl Amino Esters. Organic Letters |
| Wong N, Petronijević F, Hong AY, et al. (2019) Stereocontrolled Synthesis of Arylomycin-Based Gram-Negative Antibiotic GDC-5338. Organic Letters |
| Lim NK, Linghu X, Wong N, et al. (2018) Macrolactamization Approaches to Arylomycin Antibiotics Core. Organic Letters |
| Chen Z, Hong AY, Linghu X. (2018) Construction of Polycyclic β-Ketoesters using a Homoconjugate Addition / Decarboxylative Dieckmann Annulation Strategy. The Journal of Organic Chemistry |
| Linghu X, Segraves NL, Abramovich I, et al. (2018) Cover Feature: Highly Efficient Synthesis of a Staphylococcus aureus Targeting Payload to Enable the First Antibody–Antibiotic Conjugate (Chem. Eur. J. 12/2018) Chemistry: a European Journal. 24: 2792-2792 |
| Linghu X, Segraves N, Abramovich I, et al. (2017) Highly Efficient Synthesis of a Staphylococcus aureus-targeting Payload, Enabling the First Antibody-Antibiotic Conjugate. Chemistry (Weinheim An Der Bergstrasse, Germany) |
| Linghu X, Wong N, Jost V, et al. (2017) Kumada–Corriu Heteroaryl Cross-Coupling for Synthesis of a Pharmaceutical Intermediate: Comparison of Batch Versus Continuous Reaction Modes Organic Process Research & Development. 21: 1320-1325 |
| Linghu X, Wong N, Iding H, et al. (2017) Development of a Practical Synthesis of ERK Inhibitor GDC-0994 Organic Process Research & Development. 21: 387-398 |
| Yang S, Linghu X, Smith E, et al. (2017) Synthesis of bicyclic β-lactamase inhibitor relabactam derivatives from a relabactam intermediate Tetrahedron Letters. 58: 2838-2841 |
| Staben LR, Koenig SG, Lehar SM, et al. (2016) Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody-drug conjugates. Nature Chemistry. 8: 1112-1119 |