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Irwin M. Chaiken

Biochemistry Drexel University College of Medicine, Philadelphia, PA, United States 
protein recognition, protein machine that controls HIV-1 cell entry into host cells
"Irwin M. Chaiken"

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Emil L. Smith grad student 1968 UCLA
 (Studies of the Catalytic Center of Papain)
Christian B. Anfinsen post-doc 1969-1970 NIH
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Gupta M, Canziani G, Ang CG, et al. (2023) Pharmacophore Variants of the Macrocyclic Peptide Triazole Inactivator of HIV-1 Env. Research Square
Cusimano GM, Gary EN, Bell MR, et al. (2022) Improved Durability to SARS-CoV-2 Vaccine Immunity following Coimmunization with Molecular Adjuvant Adenosine Deaminase-1. Journal of Immunology (Baltimore, Md. : 1950). 209: 118-127
Zhang S, Holmes AP, Dick A, et al. (2021) Altered Env conformational dynamics as a mechanism of resistance to peptide-triazole HIV-1 inactivators. Retrovirology. 18: 31
Ang CG, Carter E, Haftl A, et al. (2021) Peptide Triazole Thiol Irreversibly Inactivates Metastable HIV-1 Env by Accessing Conformational Triggers Intrinsic to Virus-Cell Entry. Microorganisms. 9
Gaffney A, Nangarlia A, Ang CG, et al. (2021) HIV-1 Env-Dependent Cell Killing by Bifunctional Small-Molecule/Peptide Conjugates. Acs Chemical Biology
Parajuli B, Acharya K, Nangarlia A, et al. (2020) Identification of a glycan cluster in gp120 essential for irreversible HIV-1 lytic inactivation by a lectin-based recombinantly engineered protein conjugate. The Biochemical Journal
Gossert ST, Parajuli B, Chaiken I, et al. (2020) Roles of Variable Linker Length in Dual Acting Virucidal Entry Inhibitors on HIV-1 Potency via On-the-fly Free Energy Molecular Simulations. Protein Science : a Publication of the Protein Society
Prévost J, Tolbert WD, Medjahed H, et al. (2020) The HIV-1 Env gp120 Inner Domain Shapes the Phe43 Cavity and the CD4 Binding Site. Mbio. 11
Ang CG, Hossain MA, Rajpara M, et al. (2020) Metastable HIV-1 Surface Protein Env Sensitizes Cell Membranes to Transformation and Poration by Dual-Acting Virucidal Entry Inhibitors. Biochemistry
Aneja R, Grigoletto A, Nangarlia A, et al. (2019) Pharmacokinetic stability of macrocyclic peptide triazole HIV-1 inactivators alone and in liposomes. Journal of Peptide Science : An Official Publication of the European Peptide Society. e3155
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