Spandan Chennamadhavuni

Affiliations: 
Boston University, Boston, MA, United States 
Area:
Organic synthesis, Medicinal chemistry, Computational chemistry
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"Spandan Chennamadhavuni"
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SNBCP

Parents

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Huw M. L. Davies grad student 2012 Emory
 (Synthesis of small molecule therapeutics utilizing rhodium carbenoid chemistry.)
John A. Porco post-doc 2012-2014
Nathanael Gray post-doc 2014-2015
Dennis C. Liotta research scientist 2015-

Collaborators

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Ari Melnick collaborator (Cell Biology Tree)
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Publications

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Hatcher JM, Du G, Fontán L, et al. (2019) Peptide-based covalent inhibitors of MALT1 paracaspase. Bioorganic & Medicinal Chemistry Letters
Trilles R, Beglov D, Chen Q, et al. (2019) Discovery of macrocyclic inhibitors of Apurinic/apyrimidinic endonuclease 1. Journal of Medicinal Chemistry
Shoji M, Qian WP, Nagaraju GP, et al. (2018) Inhibition of breast cancer metastasis to the lungs with UBS109. Oncotarget. 9: 36102-36109
Chennamadhavuni S, Panek JS, Porco JA, et al. (2018) Diastereodivergent synthesis of chiral tetrahydropyrrolodiazepinediones via a one-pot intramolecular aza-Michael/lactamization sequence. The Journal of Organic Chemistry
Fontán L, Qiao Q, Hatcher JM, et al. (2018) Specific covalent inhibition of MALT1 paracaspase suppresses B cell lymphoma growth. The Journal of Clinical Investigation
Fontan L, Scott D, Hatcher J, et al. (2017) Abstract LB-303: Substrate-mimetic covalent inhibitor of MALT1 is most effective against CARD11 mutant ABC-DLBCL Cancer Research. 77
Yeo AT, Chennamadhavuni S, Whitty A, et al. (2015) Inhibition of Oncogenic Transcription Factor REL by the Natural Product Derivative Calafianin Monomer 101 Induces Proliferation Arrest and Apoptosis in Human B-Lymphoma Cell Lines. Molecules (Basel, Switzerland). 20: 7474-94
Villar EA, Beglov D, Chennamadhavuni S, et al. (2014) How proteins bind macrocycles. Nature Chemical Biology. 10: 723-31
Chepiga KM, Qin C, Alford JS, et al. (2013) Guide to Enantioselective Dirhodium(II)-Catalyzed Cyclopropanation with Aryldiazoacetates. Tetrahedron. 69
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