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David A. Spiegel, Ph.D., MD

2007- Chemistry Yale University, New Haven, CT 
natural product synthesis
"David A. Spiegel"

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John Louis Wood grad student 2005 Yale
 (Synthetic approaches to the phomoidride carbocyclic core and applications.)
Stuart L. Schreiber post-doc 2005-2007 Harvard


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Alexander Chamessian research assistant 2010 Yale
Caitlin Sengelaub research assistant 2010 Yale
Ee-Lynn Yap research assistant 2012 Yale
Andrew X. Zhang grad student 2007-2012 Yale
Patrick J. McEnaney grad student 2007-2013 Yale
Christopher G. Parker grad student 2007-2013 Yale
Eugene F Douglass grad student 2014 Yale
Tina Wang grad student 2015 Yale
Brett Blakeley post-doc Yale
Cristian Draghici post-doc Yale
Anthony F. Rullo post-doc 2014- Yale
Thi Trinh post-doc 2014- Yale
Kung-pern Wang post-doc 2014- Yale
Ryan P. Murelli post-doc 2007-2010 Yale
Rendy Kartika post-doc 2011 Yale
Dianna L. Bartel research scientist Yale
Viswanathan Muthusamy research scientist 2008- Yale
Takuji Shoda research scientist 2012 Yale
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Caianiello DF, Zhang M, Ray JD, et al. (2021) Bifunctional small molecules that mediate the degradation of extracellular proteins. Nature Chemical Biology
Douglass EF, Spiegel DA. (2021) Comment on a suite of mathematical solutions to describe ternary complex formation and their application to targeted protein degradation by heterobifunctional ligands. The Journal of Biological Chemistry. 296: 100331
Baumann T, Dunkel A, Schmid C, et al. (2020) Regulatory myeloid cells paralyze T cells through cell-cell transfer of the metabolite methylglyoxal. Nature Immunology. 21: 555-566
De Coen R, Nuhn L, Perera C, et al. (2019) A synthetic rhamnose glycopolymer cell surface receptor for endogenous antibody recruitment. Biomacromolecules
Sabbasani VR, Wang KP, Streeter MD, et al. (2019) One-Step Synthesis of 2,5-Diaminoimidazoles and Total Synthesis of Methylglyoxal-Derived Imidazolium Crosslink (MODIC). Angewandte Chemie (International Ed. in English)
Galligan JJ, Wepy JA, Streeter MD, et al. (2018) Methylglyoxal-derived posttranslational arginine modifications are abundant histone marks. Proceedings of the National Academy of Sciences of the United States of America
Leung JC, Bedermann AA, Njardarson JT, et al. (2017) Total Synthesis of (±)-Phomoidride D. Angewandte Chemie (International Ed. in English)
Chirkin E, Muthusamy V, Mann P, et al. (2017) Neutralization of pathogenic fungi with small-molecule immunotherapeutics. Angewandte Chemie (International Ed. in English)
Sankaranarayanan S, Jamshed M, Kumar A, et al. (2017) Glyoxalase Goes Green: The Expanding Roles of Glyoxalase in Plants. International Journal of Molecular Sciences. 18
Vastl J, Wang T, Trinh TB, et al. (2017) Encoded Silicon-Chip-Based Platform for Combinatorial Synthesis and Screening. Acs Combinatorial Science
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