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Jia Zhou, PhD

Affiliations: 
University of Texas Medical Branch, Galveston, TX 
Area:
Medicinal Chemistry
Website:
https://scmm.utmb.edu/faculty/f_zhou.asp
Google:
"Jia Zhou"
Bio:

My research interests are broadly based on the interface of synthetic organic chemistry and medicinal chemistry, and in particular on the drug discovery of bioactive molecules to probe biological systems or act as potential therapeutic agents in neuroscience, cancer/inflammation, infectious diseases, and other human conditions.
- https://scmm.utmb.edu/faculty/f_zhou.asp

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Parents

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Ruyu Chen grad student 1994-1997
Sidney M. Hecht post-doc 1999-2001
Alan P. Kozikowski post-doc 2001-2003

Children

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Eric A. Wold grad student 2015- UTMB

Collaborators

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Publications

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Murphy RE, Wang P, Ali S, et al. (2024) Discovery of 3-((4-Benzylpyridin-2-yl)amino)benzamides as Potent GPR52 G Protein-Biased Agonists. Journal of Medicinal Chemistry
Chen J, Garcia EJ, Merritt CR, et al. (2023) Discovery of Novel Oleamide Analogues as Brain-Penetrant Positive Allosteric Serotonin 5-HT Receptor and Dual 5-HT/5-HT Receptor Modulators. Journal of Medicinal Chemistry
Xu J, Shi S, Liu G, et al. (2022) Design, synthesis, and pharmacological evaluations of pyrrolo[1,2-a]quinoxaline-based derivatives as potent and selective sirt6 activators. European Journal of Medicinal Chemistry. 246: 114998
Liu Z, Li Y, Chen H, et al. (2022) Discovery, X-ray Crystallography, and Anti-inflammatory Activity of Bromodomain-containing Protein 4 (BRD4) BD1 Inhibitors Targeting a Distinct New Binding Site. Journal of Medicinal Chemistry
Liu Z, Wang P, Wold EA, et al. (2021) Small-Molecule Inhibitors Targeting the Canonical WNT Signaling Pathway for the Treatment of Cancer. Journal of Medicinal Chemistry
Xu J, Berastegui-Cabrera J, Carretero-Ledesma M, et al. (2021) Discovery of a Small Molecule Inhibitor of Human Adenovirus Capable of Preventing Escape from the Endosome. International Journal of Molecular Sciences. 22
Ye N, Qin W, Tian S, et al. (2020) Small Molecules Selectively Targeting Sigma-1 Receptor for the Treatment of Neurological Diseases. Journal of Medicinal Chemistry
Li Z, Xu J, Lang Y, et al. (2020) JMX0207, a niclosamide derivative with improved pharmacokinetics, suppresses Zika virus infection both in vitro and in vivo. Acs Infectious Diseases
Zhou Z, Li X, Liu Z, et al. (2020) A Bromodomain-Containing Protein 4 (BRD4) Inhibitor Suppresses Angiogenesis by Regulating AP-1 Expression. Frontiers in Pharmacology. 11: 1043
Dvorak NM, Wadsworth PA, Wang P, et al. (2020) Bidirectional Modulation of the Voltage-Gated Sodium (Nav1.6) Channel by Rationally Designed Peptidomimetics. Molecules (Basel, Switzerland). 25
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