Manoj K Kashyap, PhD

Affiliations: 
2019- Stem Cell Institute Amity University Haryana 
Area:
RNA Splicing, Tumor-microenvironment, and Natural products for Cancer Therapeutics Development
Website:
https://manojkkashyap.wixsite.com/thekashyaplab
Google:
"Kashyap, Manoj"
Bio:

Since Aug 2019, I am an associate professor at the Stem Cell Institute of the Amity University Haryana, Manesar (Gurugram). I am also an Honorary Adjunct Professor at the School of Biotechnology, Shoolini University, Solan since March 2015. Prior of joining Glocal University, I completed my postdoctoral fellowship from the Moores Cancer Center, University of California, San Diego (Jan 2012-Jan 2017) in the group of Prof(s). Michael D. Burkart, Michael Y. Choi, and Januario E. Castro. I earned my PhD in a joint PhD program by the Johns Hopkins University School of Medicine, Baltimore-Institute of Bioinformatics, Bangalore under the mentorship of Prof. Akhilesh Pandey. During stay at Johns Hopkins School of Medicine, Baltimore, I learned cutting edge technology e.g. DNA microarrays, mass spectrometry & cancer signaling, and also worked in a collaborative project on lung cancer signaling with Dr(s). Harold E. Varmus/ Udayan Guha (NCI). During Ph.D. work, I studied the molecular mechanism of tumorigenesis in esophageal cancers using DNA microarrays and quantitative proteomics using mass spectrometry. Currently, I am involved in finding the molecular mechanism of RNA splicing using splicing modulators in gastro-intestinal cancers through genomics/proteomics approaches. Additionally, I am involved in targeting the receptor-ligand axis to overcome the protection by the tumor microenvironment, its relevance in GI malignancies using anti-receptor antibodies/small molecules.
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Publications

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Kumar D, Kashyap MK, Yu Z, et al. (2022) Modulation of RNA splicing associated with Wnt signaling pathway using FD-895 and pladienolide B. Aging. 14: 2081-2100
Rao R, Husain A, Bharti AC, et al. (2019) Discovery of a novel connecting link between Renin-Angiotensin System and cancer in Barrett's Esophagus by Proteomic screening Proteomics Clin Appl
Tungekar A, Mandarthi S, Mandaviya PR, et al. (2018) ESCC ATLAS: A population wide compendium of biomarkers for Esophageal Squamous Cell Carcinoma. Scientific Reports. 8: 12715
Barbhuiya MA, Kashyap MK, Puttamallesh VN, et al. (2018) Identification of spleen tyrosine kinase as a potential therapeutic target for esophageal squamous cell carcinoma using reverse phase protein arrays. Oncotarget. 9: 18422-18434
Kashyap MK, Amaya-Chanaga CI, Kumar D, et al. (2017) Targeting the CXCR4 pathway using a novel anti-CXCR4 IgG1 antibody (PF-06747143) in chronic lymphocytic leukemia. Journal of Hematology & Oncology. 10: 112
Leon B, Kashyap M, Chan W, et al. (2017) A Challenging Pie to Splice: Drugging the Spliceosome. Angewandte Chemie (International Ed. in English)
Zhang X, Maity T, Kashyap MK, et al. (2017) Quantitative tyrosine phosphoproteomics of EGFR tyrosine kinase inhibitor-treated lung adenocarcinoma cells reveals potential novel biomarkers of therapeutic response. Molecular & Cellular Proteomics : McP
León B, Kashyap MK, Chan WC, et al. (2017) Das Spliceosom als Angriffspunkt für Pharmaka Angewandte Chemie. 129: 12218-12230
Barile E, Marconi GD, De SK, et al. (2016) hBfl-1/hNOXA Interaction Studies Provide New Insights on the Role of Bfl-1 in Cancer Cell Resistance and for the Design of Novel Anticancer Agents. Acs Chemical Biology
Choi MY, Kashyap MK, Kumar D. (2016) The chronic lymphocytic leukemia microenvironment: Beyond the B-cell receptor. Best Practice & Research. Clinical Haematology. 29: 40-53
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