Tom J. Brett
Affiliations: | Washington University, Saint Louis, St. Louis, MO |
Area:
crystallography; asthma; immunology; neurodegenerative diseasesGoogle:
"Tom Brett"Mean distance: (not calculated yet)
Parents
Sign in to add mentorJohn J. Stezowski | grad student | 1993-1999 | University of Nebraska - Lincoln |
Daved H. Fremont | post-doc | 1999-2007 | Washington University School of Medicine |
Children
Sign in to add traineeZeynep Yurtsever | grad student | 2011-2016 | Washington University |
Daniel L. Kober | grad student | 2012-2017 | Washington University |
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Publications
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Kober DL, Stuchell-Brereton MD, Kluender CE, et al. (2020) Functional insights from biophysical study of TREM2 interactions with apoE and Aβ. Alzheimer's & Dementia : the Journal of the Alzheimer's Association |
Berry KN, Brett TJ. (2020) Structural and Biophysical Analysis of the CLCA1 VWA Domain Suggests Mode of TMEM16A Engagement. Cell Reports. 30: 1141-1151.e3 |
Deming Y, Filipello F, Cignarella F, et al. (2019) The gene cluster is a key modulator of soluble TREM2 and Alzheimer's disease risk. Science Translational Medicine. 11 |
Kober D, Kluender C, Brett T. (2019) P4-172: BIOPHYSICAL INVESTIGATION OF THE TREM2 INTERACTIONS WITH APOE AND AMYLOID BETA1-42 REVEAL TWO DISTINCT BINDING SURFACES AND A POTENTIAL ROLE FOR STREM2 AS AN INHIBITOR OF AMYLOID BETA1-42 POLYMERIZATION Alzheimer's & Dementia. 15: P1340-P1340 |
Chanthamontri CK, Jordan D, Wang W, et al. (2018) Ebola Viral Protein 35 N-terminus is a Parallel Tetramer. Biochemistry |
Ohlemacher SI, Xu Y, Kober DL, et al. (2018) YbtT is a low-specificity type II thioesterase that maintains production of the metallophore yersiniabactin in pathogenic enterobacteria. The Journal of Biological Chemistry |
Berry KN, Kober DL, Su A, et al. (2018) Limiting Respiratory Viral Infection by Targeting Antiviral and Immunological Functions of BST-2/Tetherin: Knowledge and Gaps. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. e1800086 |
Kober DL, Brett TJ. (2017) TREM2-ligand interactions in health and disease. Journal of Molecular Biology |
Sala-Rabanal M, Yurtsever Z, Berry KN, et al. (2017) Modulation of TMEM16A Channel Activity by the Von Willebrand Factor Type A (VWA) domain of the Calcium-Activated Chloride Channel Regulator 1 (CLCA1). The Journal of Biological Chemistry |
Kober DL, Alexander-Brett JM, Karch CM, et al. (2016) Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms. Elife. 5 |