Edward W. Tate, Ph.D.

Chemistry Imperial College, London, London, England, United Kingdom 
chemical Biology, organic chemistry, medicinal chemistry
"Ed Tate Imperial"
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Jamshidiha M, Lanyon-Hogg T, Sutherell CL, et al. (2021) Identification of the first structurally validated covalent ligands of the small GTPase RAB27A. Rsc Medicinal Chemistry. 13: 150-155
Panyain N, Godinat A, Thawani AR, et al. (2021) Activity-based protein profiling reveals deubiquitinase and aldehyde dehydrogenase targets of a cyanopyrrolidine probe. Rsc Medicinal Chemistry. 12: 1935-1943
Benns HJ, Wincott CJ, Tate EW, et al. (2020) Activity- and reactivity-based proteomics: Recent technological advances and applications in drug discovery. Current Opinion in Chemical Biology. 60: 20-29
Broncel M, Dominicus C, Vigetti L, et al. (2020) Profiling of myristoylation in reveals an -myristoylated protein important for host cell penetration. Elife. 9
Panyain N, Godinat A, Lanyon-Hogg T, et al. (2020) Discovery of a potent and selective covalent inhibitor and activity-based probe for the deubiquitylating enzyme UCHL1, with anti-fibrotic activity. Journal of the American Chemical Society
Bell AS, Yu Z, Hutton JA, et al. (2020) Novel thienopyrimidine inhibitors of -myristoyltransferase with on-target activity in intracellular amastigotes. Journal of Medicinal Chemistry
Anderson DP, Benns HJ, Tate EW, et al. (2020) CRISPR-TAPE: protein-centric CRISPR guide design for targeted proteome engineering. Molecular Systems Biology. 16: e9475
Shchepinova MM, Hanyaloglu AC, Frost GS, et al. (2020) Chemical biology of noncanonical G protein-coupled receptor signaling: Toward advanced therapeutics. Current Opinion in Chemical Biology. 56: 98-110
Saunders CN, Cota E, Baum J, et al. (2020) Peptide Probes for MyoA Tail Interacting Protein (MTIP): Exploring the Druggability of the Malaria Parasite Motor Complex. Acs Chemical Biology
Maneiro M, Forte N, Shchepinova MM, et al. (2020) Antibody-PROTAC conjugates enable HER2-dependent targeted protein degradation of BRD4. Acs Chemical Biology
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