Pouria Dasmeh, Ph.D

Affiliations: 
2023- Human Genetics Marburg university 
Area:
Biophysics, Molecular evolution
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"Pouria Dasmeh"
Bio:

I am a computational biologist and am interested in the mechanistic understanding of cellular biology. I received my Ph.D. in computational chemistry/biology from the Technical University of Denmark working with Prof. Kasper P. Kepp and jointly accomplished my thesis in the laboratory of Prof. Eugene Shakhnovich at Harvard University. My research spans a wide range of frameworks in bioinformatics and computational biology from next-generation sequence analysis to molecular simulations. In particular, I am always keen to use newly developed technologies such as single-cell RNA-seq and proteomics to better understand cellular biology. As a group leader at the center for human genetics of Marburg University, I work on omics integration for the biological interpretation of the genome-wide association signals of complex diseases.

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Publications

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Ranganathan S, Dasmeh P, Furniss S, et al. (2023) Phosphorylation sites are evolutionary checkpoints against liquid-solid transition in protein condensates. Proceedings of the National Academy of Sciences of the United States of America. 120: e2215828120
Karve S, Dasmeh P, Zheng J, et al. (2022) Low protein expression enhances phenotypic evolvability by intensifying selection on folding stability. Nature Ecology & Evolution
Dasmeh P, Doronin R, Wagner A. (2021) The length scale of multivalent interactions is evolutionarily conserved in fungal and vertebrate phase-separating proteins. Genetics
Dasmeh P, Wagner A. (2021) Yeast Proteins may Reversibly Aggregate like Amphiphilic Molecules. Journal of Molecular Biology. 434: 167352
Razban RM, Dasmeh P, Serohijos AWR, et al. (2021) Avoidance of protein unfolding constrains protein stability in long-term evolution. Biophysical Journal
Dasmeh P, Wagner A. (2020) Natural selection on the phase-separation properties of FUS during 160 million years of mammalian evolution. Molecular Biology and Evolution
Dasmeh P, Serohijos AWR. (2018) Estimating the contribution of folding stability to non-specific epistasis in protein evolution. Proteins
Dasmeh P, Girard É, Serohijos AWR. (2017) Highly expressed genes evolve under strong epistasis from a proteome-wide scan in E. coli. Scientific Reports. 7: 15844
Dasmeh P, Kepp KP. (2017) Superoxide dismutase 1 is positively selected to minimize protein aggregation in great apes. Cellular and Molecular Life Sciences : Cmls
Holm J, Dasmeh P, Kepp KP. (2016) Tracking evolution of myoglobin stability in cetaceans using experimentally calibrated computational methods that account for generic protein relaxation. Biochimica Et Biophysica Acta. 1864: 825-34
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