Liu Deng, Ph.D.

Affiliations: 
2005 Duke University, Durham, NC 
Area:
Organic Chemistry, Pharmaceutical Chemistry
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Michael C. Pirrung grad student 2005 Duke
 (Synthesis of analogues of DAQ B1 as potential anti-diabetic drugs.)
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Publications

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Pirrung MC, Deng L, Lin B, et al. (2008) Quinone replacements for small molecule insulin mimics. Chembiochem : a European Journal of Chemical Biology. 9: 360-2
Lin B, Li Z, Park K, et al. (2007) Identification of novel orally available small molecule insulin mimetics. The Journal of Pharmacology and Experimental Therapeutics. 323: 579-85
Kim H, Deng L, Xiong X, et al. (2007) Glyceraldehyde 3-phosphate dehydrogenase is a cellular target of the insulin mimic demethylasterriquinone B1. Journal of Medicinal Chemistry. 50: 3423-6
Lin B, Pirrung MC, Deng L, et al. (2007) Neuroprotection by small molecule activators of the nerve growth factor receptor. The Journal of Pharmacology and Experimental Therapeutics. 322: 59-69
Pirrung MC, Liu Y, Deng L, et al. (2005) Methyl scanning: total synthesis of demethylasterriquinone B1 and derivatives for identification of sites of interaction with and isolation of its receptor(s). Journal of the American Chemical Society. 127: 4609-24
Sohn J, Kiburz B, Li Z, et al. (2003) Inhibition of Cdc25 phosphatases by indolyldihydroxyquinones. Journal of Medicinal Chemistry. 46: 2580-8
Pirrung MC, Deng L, Li Z, et al. (2002) Synthesis of 2,5-dihydroxy-3-(indol-3-yl)benzoquinones by acid-catalyzed condensation of indoles with 2,5-dichlorobenzoquinone. The Journal of Organic Chemistry. 67: 8374-88
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