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Paul C. Engel, D.Phil

Affiliations: 
1970-1994 University of Sheffield, Sheffield, England, United Kingdom 
 1994- Biomolecular & Biomedical Science University College Dublin, Dublin, County Dublin, Ireland 
Area:
Enzymology
Website:
http://www.ucd.ie/research/people/biomolecularbiomedscience/professorpaulengel/
Google:
"Paul Engel"
Mean distance: 16.05
 

Parents

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Vincent Massey grad student
Keith Dalziel grad student 1968 Oxford
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Publications

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Yu X, Wang X, Engel PC. (2014) The specificity and kinetic mechanism of branched-chain amino acid aminotransferase from Escherichia coli studied with a new improved coupled assay procedure and the enzyme's potential for biocatalysis. The Febs Journal. 281: 391-400
Engel PC. (2014) Glutamate dehydrogenases: the why and how of coenzyme specificity. Neurochemical Research. 39: 426-32
Sharkey MA, Oliveira TF, Engel PC, et al. (2013) Structure of NADP(+)-dependent glutamate dehydrogenase from Escherichia coli--reflections on the basis of coenzyme specificity in the family of glutamate dehydrogenases. The Febs Journal. 280: 4681-92
Munawar N, Engel PC. (2013) Prospects for robust biocatalysis: engineering of novel specificity in a halophilic amino acid dehydrogenase. Extremophiles : Life Under Extreme Conditions. 17: 43-51
Yu X, Bresser J, Schall I, et al. (2012) Development of a satisfactory and general continuous assay for aminotransferases by coupling with (R)-2-hydroxyglutarate dehydrogenase. Analytical Biochemistry. 431: 127-31
Sharkey MA, Gori A, Capone M, et al. (2012) Reversal of the extreme coenzyme selectivity of Clostridium symbiosum glutamate dehydrogenase. The Febs Journal. 279: 3003-9
Munawar N, Engel PC. (2012) Overexpression in a non-native halophilic host and biotechnological potential of NAD+-dependent glutamate dehydrogenase from Halobacterium salinarum strain NRC-36014. Extremophiles : Life Under Extreme Conditions. 16: 463-76
Oliveira T, Panjikar S, Carrigan JB, et al. (2012) Crystal structure of NAD+-dependent Peptoniphilus asaccharolyticus glutamate dehydrogenase reveals determinants of cofactor specificity. Journal of Structural Biology. 177: 543-52
Griffin J, Engel PC. (2011) An Examination by Site-Directed Mutagenesis of Putative Key Residues in the Determination of Coenzyme Specificity in Clostridial NAD-Dependent Glutamate Dehydrogenase. Enzyme Research. 2011: 595793
Wang XT, Mion B, Aherne A, et al. (2011) Molecular recruitment as a basis for negative dominant inheritance? propagation of misfolding in oligomers of IMPDH1, the mutated enzyme in the RP10 form of retinitis pigmentosa. Biochimica Et Biophysica Acta. 1812: 1472-6
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