James Dowden, Ph.D

1996-1999 Chemistry University of Edinburgh, Edinburgh, Scotland, United Kingdom 
 1999-2005 Chemistry University of Bath, Bath, England, United Kingdom 
 2005- Chemistry University of Nottingham, Nottingham, England, United Kingdom 
Natural product synthesis, Biochemistry
"James Dowden"
Mean distance: 9.15
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Day J, McKeever-Abbas B, Dowden J. (2016) Stereoselective Synthesis of Tetrahydroindolizines through the Catalytic Formation of Pyridinium Ylides from Diazo Compounds. Angewandte Chemie (International Ed. in English)
Hanson-Heine MW, Wriglesworth A, Uroos M, et al. (2015) Calculating singlet excited states: Comparison with fast time-resolved infrared spectroscopy of coumarins. The Journal of Chemical Physics. 142: 154119
Day J, Uroos M, Castledine RA, et al. (2013) Alkaloid inspired spirocyclic oxindoles from 1,3-dipolar cycloaddition of pyridinium ylides. Organic & Biomolecular Chemistry. 11: 6502-9
You B, Hamer K, Lewis W, et al. (2013) An unusual silicon mediated transannular cyclopropanation. Chemical Communications (Cambridge, England). 49: 795-7
Dowden J, Pike RA, Parry RV, et al. (2011) Small molecule inhibitors that discriminate between protein arginine N-methyltransferases PRMT1 and CARM1. Organic & Biomolecular Chemistry. 9: 7814-21
Hong W, Dowden J. (2011) Facile synthesis of N-6 adenosine modified analogue toward S-adenosyl methionine derived probe for protein arginine methyltransferases Chinese Chemical Letters. 22: 1439-1442
Dowden J, Hong W, Parry RV, et al. (2010) Toward the development of potent and selective bisubstrate inhibitors of protein arginine methyltransferases. Bioorganic & Medicinal Chemistry Letters. 20: 2103-5
Stevenson B, Lewis W, Dowden J. (2010) Expedient route to an amine precursor of halichlorine and pinnaic acid from nitrocyclopent-1-ene Synlett. 672-674
Dammermann W, Zhang B, Nebel M, et al. (2009) NAADP-mediated Ca2+ signaling via type 1 ryanodine receptor in T cells revealed by a synthetic NAADP antagonist. Proceedings of the National Academy of Sciences of the United States of America. 106: 10678-83
Parkesh R, Lewis AM, Aley PK, et al. (2008) Cell-permeant NAADP: a novel chemical tool enabling the study of Ca2+ signalling in intact cells. Cell Calcium. 43: 531-8
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