John F. W. Keana

1965- University of Oregon, Eugene, OR, United States 
"John Keana"
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Birrell GB, Zaikova TO, Rukavishnikov AV, et al. (2003) Allosteric interactions within subsites of a monomeric enzyme: kinetics of fluorogenic substrates of PI-specific phospholipase C. Biophysical Journal. 84: 3264-75
Zhou ZL, Kher SM, Cai SX, et al. (2003) Synthesis and SAR of novel di- and trisubstituted 1,4-dihydroquinoxaline-2,3-diones related to licostinel (Acea 1021) as NMDA/glycine site antagonists. Bioorganic & Medicinal Chemistry. 11: 1769-80
Ryan M, Zaikova TO, Keana JF, et al. (2002) Listeria monocytogenes phosphatidylinositol-specific phospholipase C: activation and allostery. Biophysical Chemistry. 101: 347-58
Zhou ZL, Navratil JM, Cai SX, et al. (2001) Synthesis and SAR of 5-, 6-, 7- and 8-aza analogues of 3-aryl-4-hydroxyquinolin-2(1H)-one as NMDA/glycine site antagonists. Bioorganic & Medicinal Chemistry. 9: 2061-71
Guzikowski AP, Tamiz AP, Acosta-Burruel M, et al. (2000) Synthesis of N-substituted 4-(4-hydroxyphenyl)piperidines, 4-(4-hydroxybenzyl)piperidines, and (+/-)-3-(4-hydroxyphenyl)pyrrolidines: selective antagonists at the 1A/2B NMDA receptor subtype. Journal of Medicinal Chemistry. 43: 984-94
Tamiz AP, Cai SX, Zhou ZL, et al. (1999) Structure-activity relationship of N-(phenylalkyl)cinnamides as novel NR2B subtype-selective NMDA receptor antagonists. Journal of Medicinal Chemistry. 42: 3412-20
Zhou ZL, Cai SX, Whittemore ER, et al. (1999) 4-Hydroxy-1-[2-(4-hydroxyphenoxy)ethyl]-4-(4-methylbenzyl)piperidine: a novel, potent, and selective NR1/2B NMDA receptor antagonist. Journal of Medicinal Chemistry. 42: 2993-3000
Rukavishnikov AV, Zaikova TO, Birrell GB, et al. (1999) Synthesis of a new fluorogenic substrate for the continuous assay of mammalian phosphoinositide-specific phospholipase C. Bioorganic & Medicinal Chemistry Letters. 9: 1133-6
Wang Y, Konkoy CS, Ilyin VI, et al. (1998) Synthesis of 7,8-(methylenedioxy)-1-phenyl-3,5-dihydro-4H-2, 3-benzodiazepin-4-ones as novel and potent noncompetitive AMPA receptor antagonists. Journal of Medicinal Chemistry. 41: 2621-5
Rukavishnikov AV, Zaikova TO, Griffith OH, et al. (1997) Improved synthesis of myo-inositol 1-(4-nitrophenyl hydrogen phosphate), a chromogenic substrate for phosphatidylinositol-specific phospholipase C. Chemistry and Physics of Lipids. 89: 153-7
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