John Hynes
Affiliations: | University of Pennsylvania, Philadelphia, PA, United States |
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Parents
Sign in to add mentor| Ralph F. Hirschmann | grad student | ||
| Amos B. Smith, III | grad student | ||
| Larry E. Overman | post-doc |
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Publications
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| McDaniel J, Farley CA, Ramirez A, et al. (2020) Discovery of Annulating Reagents Enabling the One-Step and Highly Stereoselective Synthesis of Cyclopentyl and Cyclohexyl Cores. Organic Letters |
| Shi Q, Xiao Z, Yang MG, et al. (2020) Tricyclic Sulfones as Potent, Selective and Efficacious RORγt Inverse Agonists - Exploring C6 and C8 SAR Using Late-Stage Functionalization. Bioorganic & Medicinal Chemistry Letters. 127521 |
| Marcoux D, Beaudoin Bertrand M, Weigelt CA, et al. (2020) Annulation Reaction Enables the identification of an Exocyclic Amide Tricyclic Chemotype as Retinoic Acid Receptor-Related Orphan Receptor Gamma (RORγ/RORc) Inverse Agonists. Bioorganic & Medicinal Chemistry Letters. 127466 |
| Nair S, Kumar SR, Paidi VR, et al. (2020) Optimization of Nicotinamides as Potent and Selective IRAK4 Inhibitors with Efficacy in a Murine Model of Psoriasis. Acs Medicinal Chemistry Letters. 11: 1402-1409 |
| Shi Q, Greenwood NS, Meehan MC, et al. (2019) One-Step Diastereoselective Pyrrolidine Synthesis Using a Sulfinamide Annulating Reagent. Organic Letters |
| Marcoux D, Duan JJ, Shi Q, et al. (2019) Rationally Designed, Conformationally Constrained Inverse Agonists of RORγt ‒ Identification of a Potent, Selective Series with Biologic-Like In Vivo Efficacy. Journal of Medicinal Chemistry |
| Arunachalam PN, Kuppusamy P, Ganesan S, et al. (2019) Development of a Scalable Synthesis for the Potent Kinase Inhibitor BMS-986236; 1-(5-(4-(3-Hydroxy-3-methylbutyl)-1H-1,2,3-triazol-1-yl)-4-(isopropylamino)pyridin-2-yl)-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile Organic Process Research & Development. 23: 912-918 |
| Shi Q, Meehan MC, Galella M, et al. (2017) Protected Chloroethyl and Chloropropyl Amines as Conformationally Unrestricted Annulating Reagents. Organic Letters |
| Kempson J, Ovalle D, Guo J, et al. (2017) Discovery of highly potent, selective, covalent inhibitors of JAK3. Bioorganic & Medicinal Chemistry Letters |
| Liu Q, Shi Q, Marcoux D, et al. (2017) Identification of a potent, selective, and efficacious phosphatidylinositol 3-kinase δ (PI3Kδ) inhibitor for the treatment of immunological disorders. Journal of Medicinal Chemistry |