Jay Clemens Groppe

Texas A&M University College of Dentistry 
Biochemistry, Protein Structure and Function, BMP Signaling, Protein Kinases, Fibrodysplasia Ossificans Progressiva
"Jay Groppe"
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Daniel E. Morse grad student UC Santa Barbara
 (Chemistry-Biological Sciences Interdepartmental Program in Biochemistry-Molecular Biology)
Steve Reed grad student UC Santa Barbara (PombeTree)
 (Initially as Master's student, transferred w/o degree to Interdepartmental Biochemistry-Molecular Biology PhD program and then to laboratory of Daniel Morse.)
Markus Affolter post-doc Biozentrum, University of Basel (FlyTree)
Thomas C. Bruice post-doc UC Santa Barbara
 (One year, divided-time (50%) gap position between PhD and Postdoc in Switzerland)
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Wang H, Lindborg C, Lounev V, et al. (2016) Cellular Hypoxia Promotes Heterotopic Ossification by Amplifying BMP Signaling. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research
Kaplan FS, Kobori JA, Orellana C, et al. (2015) Multi-system involvement in a severe variant of fibrodysplasia ossificans progressiva (ACVR1 c.772G>A; R258G): A report of two patients. American Journal of Medical Genetics. Part A
Whitman M, Rosen V, Brivanlou AH, et al. (2013) Regarding the mechanism of action of a proposed peptide agonist of the bone morphogenetic protein receptor activin-like kinase 3. Nature Medicine. 19: 809-10
Zimmer J, Doelken SC, Horn D, et al. (2012) Functional analysis of alleged NOGGIN mutation G92E disproves its pathogenic relevance. Plos One. 7: e35062
Ishii Y, Takizawa T, Iwasaki H, et al. (2012) Nucleotide polymorphisms in the canine Noggin gene and their distribution among dog (Canis lupus familiaris) breeds. Biochemical Genetics. 50: 12-8
Zuniga JE, Ilangovan U, Mahlawat P, et al. (2011) The TβR-I pre-helix extension is structurally ordered in the unbound form and its flanking prolines are essential for binding. Journal of Molecular Biology. 412: 601-18
Groppe JC, Wu J, Shore EM, et al. (2011) In vitro analyses of the dysregulated R206H ALK2 kinase-FKBP12 interaction associated with heterotopic ossification in FOP. Cells, Tissues, Organs. 194: 291-5
Seemann P, Brehm A, König J, et al. (2009) Mutations in GDF5 reveal a key residue mediating BMP inhibition by NOGGIN. Plos Genetics. 5: e1000747
Nickel J, Sebald W, Groppe JC, et al. (2009) Intricacies of BMP receptor assembly. Cytokine & Growth Factor Reviews. 20: 367-77
Wang Y, Groppe JC, Wu J, et al. (2009) Pathogenic mechanisms of tooth agenesis linked to paired domain mutations in human PAX9. Human Molecular Genetics. 18: 2863-74
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