John C. Widen

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2011-2017 Medicinal Chemistry University of Minnesota, Twin Cities, Minneapolis, MN 
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Daniel A. Harki grad student 2011-2017 UMN
 (Design and Synthesis of Natural Product-Inspired, Cysteine Reactive Probes toward Inhibition of Transcription Factors and Target Identification Studies)
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Publications

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Divakaran A, Talluri SK, Ayoub AM, et al. (2018) Molecular Basis for the N-Terminal Bromodomain and Extra Terminal (BET) Family Selectivity of a Dual Kinase-Bromodomain Inhibitor. Journal of Medicinal Chemistry
Naumann JA, Widen JC, Jonart LA, et al. (2018) SN-38 conjugated gold nanoparticles activated by Ewing sarcoma specific mRNAs exhibit in vitro and in vivo efficacy. Bioconjugate Chemistry
Widen JC, Kempema AM, Baur JW, et al. (2018) Helenalin Analogues Targeting NF-κB p65: Thiol Reactivity and Cellular Potency Studies of Varied Electrophiles. Chemmedchem
Widen JC, Kempema AM, Villalta PW, et al. (2017) Targeting NF-κB p65 with a Helenalin Inspired Bis-electrophile. Acs Chemical Biology. 12: 102-113
Jackson PA, Widen JC, Harki DA, et al. (2016) Covalent Modifiers: A Chemical Perspective on the Reactivity of α,β-Unsaturated Carbonyls with Thiols via Hetero-Michael Addition Reactions. Journal of Medicinal Chemistry
Wells SM, Widen JC, Harki DA, et al. (2016) Alkyne Ligation Handles: Propargylation of Hydroxyl, Sulfhydryl, Amino, and Carboxyl Groups via the Nicholas Reaction. Organic Letters
Kempema AM, Widen JC, Hexum JK, et al. (2015) Synthesis and antileukemic activities of C1-C10-modified parthenolide analogues. Bioorganic & Medicinal Chemistry. 23: 4737-45
Wen B, Hexum JK, Widen JC, et al. (2013) A redox economical synthesis of bioactive 6,12-guaianolides. Organic Letters. 15: 2644-7
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