Rajat Rohatgi

Oncology Stanford University School of Medicine, Palo Alto, CA, United States 
Biochemical Mechanisms of Hedgehog (Hh) Signaling
"Rajat Rohatgi"


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Jack W. Szostak research assistant 1992-1994 Harvard Medical School
 (Non-Enzymatic Template-Directed Ligation Reactions of Ribooligonucleotides)
Marc W. Kirschner grad student 1997-2002 Harvard
 (Biochemical dissection of a signaling pathway that controls actin assembly.)
Matthew P. Scott post-doc 2005-2008 Stanford Medical School
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Khandwala CB, Sarkar P, Schmidt HB, et al. (2023) Direct ionic stress sensing and mitigation by the transcription factor NFAT5. Biorxiv : the Preprint Server For Biology
Ng VH, Spencer Z, Neitzel LR, et al. (2023) The USP46 complex deubiquitylates LRP6 to promote Wnt/β-catenin signaling. Nature Communications. 14: 6173
Spencer ZT, Ng VH, Benchabane H, et al. (2023) The USP46 deubiquitylase complex increases Wingless/Wnt signaling strength by stabilizing Arrow/LRP6. Nature Communications. 14: 6174
Siebold C, Rohatgi R. (2023) The Inseparable Relationship Between Cholesterol and Hedgehog Signaling. Annual Review of Biochemistry
Schmidt HB, Jaafar ZA, Wulff BE, et al. (2022) Oxaliplatin disrupts nucleolar function through biophysical disintegration. Cell Reports. 41: 111629
Lebensohn AM, Bazan JF, Rohatgi R. (2022) Receptor control by membrane-tethered ubiquitin ligases in development and tissue homeostasis. Current Topics in Developmental Biology. 150: 25-89
Griffiths SC, Schwab RA, El Omari K, et al. (2021) Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling. Nature Communications. 12: 7171
Zhao Z, Lee RTH, Pusapati GV, et al. (2021) An essential role for Grk2 in Hedgehog signalling downstream of Smoothened. Embo Reports. 22: e52895
Bosakova M, Abraham SP, Nita A, et al. (2020) Mutations in GRK2 cause Jeune syndrome by impairing Hedgehog and canonical Wnt signaling. Embo Molecular Medicine. 12: e11739
Radhakrishnan A, Rohatgi R, Siebold C. (2020) Cholesterol access in cellular membranes controls Hedgehog signaling. Nature Chemical Biology. 16: 1303-1313
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