Isaac T Schiefer

University of Toledo, Toledo, OH, United States 
CNS drug discovery
"Isaac Schiefer"
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Fà M, Zhang H, Staniszewski A, et al. (2015) Novel Selective Calpain 1 Inhibitors as Potential Therapeutics in Alzheimer's Disease. Journal of Alzheimer's Disease : Jad
Trippier PC, Zhao KT, Fox SG, et al. (2014) Proteasome activation is a mechanism for pyrazolone small molecules displaying therapeutic potential in amyotrophic lateral sclerosis. Acs Chemical Neuroscience. 5: 823-9
Schiefer IT, Tapadar S, Litosh V, et al. (2013) Design, synthesis, and optimization of novel epoxide incorporating peptidomimetics as selective calpain inhibitors. Journal of Medicinal Chemistry. 56: 6054-68
Schiefer IT, VandeVrede L, Fa' M, et al. (2012) Furoxans (1,2,5-oxadiazole-N-oxides) as novel NO mimetic neuroprotective and procognitive agents. Journal of Medicinal Chemistry. 55: 3076-87
Abdul-Hay S, Schiefer IT, Chandrasena RE, et al. (2011) NO-SSRIs: Nitric Oxide Chimera Drugs Incorporating a Selective Serotonin Reuptake Inhibitor. Acs Medicinal Chemistry Letters. 2: 656-661
Abdelhamid R, Luo J, Vandevrede L, et al. (2011) Benzothiophene Selective Estrogen Receptor Modulators Provide Neuroprotection by a novel GPR30-dependent Mechanism. Acs Chemical Neuroscience. 2: 256-268
Schiefer IT, Abdul-Hay S, Wang H, et al. (2011) Inhibition of amyloidogenesis by nonsteroidal anti-inflammatory drugs and their hybrid nitrates. Journal of Medicinal Chemistry. 54: 2293-306
Sinha V, Wijewickrama GT, Chandrasena RE, et al. (2010) Proteomic and mass spectroscopic quantitation of protein S-nitrosation differentiates NO-donors. Acs Chemical Biology. 5: 667-80
Anand S, Schiefer IT, Thatcher GRJ. (2010) Nitric oxide donor and mimetic molecules in cancer chemotherapy and chemoprevention Forum On Immunopathological Diseases and Therapeutics. 1: 251-279
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