George M Helmkamp, Jr.

1975- Biochemistry University of Kansas Medical Center, Kansas City, KS, United States 
biochemistry and molecular biology
"George Merlin Helmkamp" OR "George M Helmkamp"
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Konrad Bloch grad student 1970 Harvard
 (The molecular structure and active site of β-hydroxydecanoyl thioester dehydrase)
Laurens L.M. van Deenen post-doc 1973-1975 Utrecht
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Helmkamp GM. (2010) Activity of Phospholipid Exchange Proteins toward Gel and Liquid-Crystalline Phospholipid Vesicles. Biophysical Journal. 37: 112-3
Vordtriede PB, Doan CN, Tremblay JM, et al. (2005) Structure of PITPbeta in complex with phosphatidylcholine: comparison of structure and lipid transfer to other PITP isoforms. Biochemistry. 44: 14760-71
Miller EC, Helmkamp GM. (2003) Exposure of phosphatidylinositol transfer proteins to sphingomyelin-cholesterol membranes suggests transient but productive interactions with raft-like, liquid-ordered domains. Biochemistry. 42: 13250-9
Schroeder F, Zhou M, Swaggerty CL, et al. (2003) Sterol carrier protein-2 functions in phosphatidylinositol transfer and signaling. Biochemistry. 42: 3189-202
Li H, Tremblay JM, Yarbrough LR, et al. (2002) Both isoforms of mammalian phosphatidylinositol transfer protein are capable of binding and transporting sphingomyelin. Biochimica Et Biophysica Acta. 1580: 67-76
Tremblay JM, Li H, Yarbrough LR, et al. (2001) Modifications of cysteine residues in the solution and membrane-associated conformations of phosphatidylinositol transfer protein have differential effects on lipid transfer activity. Biochemistry. 40: 9151-8
Yoder MD, Thomas LM, Tremblay JM, et al. (2001) Structure of a multifunctional protein: Mammalian phosphatidylinositol transfer protein complexed with phosphatidylcholine Journal of Biological Chemistry. 276: 9246-9252
Oliver RL, Tremblay JM, Helmkamp GM, et al. (1999) X-ray analysis of crystals of rat phosphatidylinositol-transfer protein with bound phosphatidylcholine. Acta Crystallographica. Section D, Biological Crystallography. 55: 522-4
Tremblay JM, Voziyan PA, Helmkamp GM, et al. (1998) The C-terminus of phosphatidylinositol transfer protein modulates membrane interactions and transfer activity but not phospholipid binding. Biochimica Et Biophysica Acta. 1389: 91-100
Voziyan PA, Tremblay JM, Yarbrough LR, et al. (1997) Importance of phospholipid in the folding and conformation of phosphatidylinositol transfer protein: comparison of apo and holo species. Biochemistry. 36: 10082-8
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