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C. Denise Okafor

Affiliations: 
Georgia Institute of Technology and Emory University, Atlanta, GA, United States 
Area:
Biochemistry, computational modeling
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Parents

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Nicholas V. Hud grad student 2010-2015 Georgia Tech
Loren Dean Williams grad student 2010-2015 Penn State College
Eric A. Ortlund post-doc 2015- Emory

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Publications

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Mays SG, Hercules D, Ortlund EA, et al. (2023) The nuclear receptor LRH-1 discriminates between ligands using distinct allosteric signaling circuits. Protein Science : a Publication of the Protein Society. e4754
Mays SG, Hercules D, Ortlund EA, et al. (2023) The nuclear receptor LRH-1 discriminates between ligands using distinct allosteric signaling circuits. Biorxiv : the Preprint Server For Biology
Cato ML, Cornelison JL, Spurlin RM, et al. (2022) Differential Modulation of Nuclear Receptor LRH-1 through Targeting Buried and Surface Regions of the Binding Pocket. Journal of Medicinal Chemistry
Mays SG, D'Agostino EH, Flynn AR, et al. (2022) A phospholipid mimetic targeting LRH-1 ameliorates colitis. Cell Chemical Biology
Moody JC, Qadota H, Reedy AR, et al. (2020) The Rho-GEF PIX-1 directs assembly or stability of lateral attachment structures between muscle cells. Nature Communications. 11: 5010
Tillman MC, Imai N, Li Y, et al. (2020) Allosteric regulation of thioesterase superfamily member 1 by lipid sensor domain binding fatty acids and lysophosphatidylcholine. Proceedings of the National Academy of Sciences of the United States of America
Guth-Metzler R, Bray MS, Frenkel-Pinter M, et al. (2020) Cutting in-line with iron: ribosomal function and non-oxidative RNA cleavage. Nucleic Acids Research
Okafor CD, Hercules D, Kell SA, et al. (2019) Rewiring Ancient Residue Interaction Networks Drove the Evolution of Specificity in Steroid Receptors. Structure (London, England : 1993)
Mays S, Flynn AR, Cornelison J, et al. (2019) Development of the first low nanomolar Liver Receptor Homolog-1 agonist through structure-guided design. Journal of Medicinal Chemistry
Okafor CD, Colucci JK, Ortlund EA. (2019) Ligand-Induced Allosteric Effects Governing SR Signaling Nuclear Receptor Research. 6
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