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Nigel D. F. Grindley

Molecular Biophysics and Biochemistry Yale University, New Haven, CT 
DNA Replication and Repair
"Nigel D. F. Grindley"

Mean distance: 8.66


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Earl May grad student Yale
Robert E. Hughes grad student 1987-1992 Yale
Andres E. Leschziner grad student 2000 Yale
Angela M. DeLucia grad student 2007 Yale
Graham F. Hatfull post-doc 1984-1988 Yale
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Keenholtz RA, Grindley ND, Hatfull GF, et al. (2016) Crossover-site sequence and DNA torsional stress control strand interchanges by the Bxb1 site-specific serine recombinase. Nucleic Acids Research
Bermek O, Grindley ND, Joyce CM. (2013) Prechemistry nucleotide selection checkpoints in the reaction pathway of DNA polymerase I and roles of glu710 and tyr766. Biochemistry. 52: 6258-74
Hohlbein J, Aigrain L, Craggs TD, et al. (2013) Conformational landscapes of DNA polymerase I and mutator derivatives establish fidelity checkpoints for nucleotide insertion. Nature Communications. 4: 2131
Bai H, Kath JE, Zörgiebel FM, et al. (2012) Remote control of DNA-acting enzymes by varying the Brownian dynamics of a distant DNA end. Proceedings of the National Academy of Sciences of the United States of America. 109: 16546-51
Bai H, Sun M, Ghosh P, et al. (2011) Single-molecule analysis reveals the molecular bearing mechanism of DNA strand exchange by a serine recombinase. Proceedings of the National Academy of Sciences of the United States of America. 108: 7419-24
Bermek O, Grindley ND, Joyce CM. (2011) Distinct roles of the active-site Mg2+ ligands, Asp882 and Asp705, of DNA polymerase I (Klenow fragment) during the prechemistry conformational transitions. The Journal of Biological Chemistry. 286: 3755-66
Santoso Y, Joyce CM, Potapova O, et al. (2010) Conformational transitions in DNA polymerase I revealed by single-molecule FRET. Proceedings of the National Academy of Sciences of the United States of America. 107: 715-20
Gehman JD, Cocco MJ, Grindley ND. (2008) Chemical shift mapping of gammadelta resolvase dimer and activated tetramer: mechanistic implications for DNA strand exchange. Biochimica Et Biophysica Acta. 1784: 2086-92
Joyce CM, Potapova O, Delucia AM, et al. (2008) Fingers-closing and other rapid conformational changes in DNA polymerase I (Klenow fragment) and their role in nucleotide selectivity. Biochemistry. 47: 6103-16
DeLucia AM, Grindley ND, Joyce CM. (2007) Conformational changes during normal and error-prone incorporation of nucleotides by a Y-family DNA polymerase detected by 2-aminopurine fluorescence. Biochemistry. 46: 10790-803
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