Linda S Brinen
Affiliations: | 1994-1998 | University of California, San Francisco, San Francisco, CA |
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"Linda Sue Brinen"Mean distance: (not calculated yet)
Parents
Sign in to add mentor| Jon C. Clardy | grad student | 1987-1993 | Cornell | |
| (Structural studies of the bioactive natural products Gigantecin, Neamphine, Chlorophyllonic Acid A Methyl Ester, and structural studies of a monofunctional chorismate mutase.) | ||||
| P. Andrew (Andy) Karplus | grad student | 1991-1993 | Cornell | |
| (co-major advisor) | ||||
| Robert J. Fletterick | post-doc | 1994-1998 | UCSF | |
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Publications
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| Chen YT, Brinen LS, Kerr ID, et al. (2013) Structure of WRR-483 bound to cruzain Plos Neglected Tropical Diseases |
| Chen YT, Brinen LS, Kerr ID, et al. (2010) In vitro and in vivo studies of the trypanocidal properties of WRR-483 against Trypanosoma cruzi. Plos Neglected Tropical Diseases. 4 |
| Kerr ID, Wu P, Marion-Tsukamaki R, et al. (2010) Crystal Structures of TbCatB and rhodesain, potential chemotherapeutic targets and major cysteine proteases of Trypanosoma brucei. Plos Neglected Tropical Diseases. 4: e701 |
| He C, Nora GP, Schneider EL, et al. (2010) A novel Entamoeba histolytica cysteine proteinase, EhCP4, is key for invasive amebiasis and a therapeutic target. The Journal of Biological Chemistry. 285: 18516-27 |
| Brak K, Kerr ID, Barrett KT, et al. (2010) Nonpeptidic tetrafluorophenoxymethyl ketone cruzain inhibitors as promising new leads for Chagas disease chemotherapy. Journal of Medicinal Chemistry. 53: 1763-73 |
| Bryant C, Kerr ID, Debnath M, et al. (2009) Novel non-peptidic vinylsulfones targeting the S2 and S3 subsites of parasite cysteine proteases. Bioorganic & Medicinal Chemistry Letters. 19: 6218-21 |
| Kerr ID, Lee JH, Farady CJ, et al. (2009) Vinyl sulfones as antiparasitic agents and a structural basis for drug design. The Journal of Biological Chemistry. 284: 25697-703 |
| Kerr ID, Lee JH, Pandey KC, et al. (2009) Structures of falcipain-2 and falcipain-3 bound to small molecule inhibitors: implications for substrate specificity. Journal of Medicinal Chemistry. 52: 852-7 |
| Huang R, Que X, Hirata K, et al. (2009) The cathepsin L of Toxoplasma gondii (TgCPL) and its endogenous macromolecular inhibitor, toxostatin. Molecular and Biochemical Parasitology. 164: 86-94 |
| Stack CM, Caffrey CR, Donnelly SM, et al. (2008) Structural and functional relationships in the virulence-associated cathepsin L proteases of the parasitic liver fluke, Fasciola hepatica. The Journal of Biological Chemistry. 283: 9896-908 |