Linda S Brinen

1994-1998 University of California, San Francisco, San Francisco, CA 
"Linda Sue Brinen"
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Jon C. Clardy grad student 1987-1993 Cornell
 (Structural studies of the bioactive natural products Gigantecin, Neamphine, Chlorophyllonic Acid A Methyl Ester, and structural studies of a monofunctional chorismate mutase.)
P. Andrew (Andy) Karplus grad student 1991-1993 Cornell
 (co-major advisor)
Robert J. Fletterick post-doc 1994-1998 UCSF
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Chen YT, Brinen LS, Kerr ID, et al. (2013) Structure of WRR-483 bound to cruzain Plos Neglected Tropical Diseases
Chen YT, Brinen LS, Kerr ID, et al. (2010) In vitro and in vivo studies of the trypanocidal properties of WRR-483 against Trypanosoma cruzi. Plos Neglected Tropical Diseases. 4
Kerr ID, Wu P, Marion-Tsukamaki R, et al. (2010) Crystal Structures of TbCatB and rhodesain, potential chemotherapeutic targets and major cysteine proteases of Trypanosoma brucei. Plos Neglected Tropical Diseases. 4: e701
He C, Nora GP, Schneider EL, et al. (2010) A novel Entamoeba histolytica cysteine proteinase, EhCP4, is key for invasive amebiasis and a therapeutic target. The Journal of Biological Chemistry. 285: 18516-27
Brak K, Kerr ID, Barrett KT, et al. (2010) Nonpeptidic tetrafluorophenoxymethyl ketone cruzain inhibitors as promising new leads for Chagas disease chemotherapy. Journal of Medicinal Chemistry. 53: 1763-73
Bryant C, Kerr ID, Debnath M, et al. (2009) Novel non-peptidic vinylsulfones targeting the S2 and S3 subsites of parasite cysteine proteases. Bioorganic & Medicinal Chemistry Letters. 19: 6218-21
Kerr ID, Lee JH, Farady CJ, et al. (2009) Vinyl sulfones as antiparasitic agents and a structural basis for drug design. The Journal of Biological Chemistry. 284: 25697-703
Kerr ID, Lee JH, Pandey KC, et al. (2009) Structures of falcipain-2 and falcipain-3 bound to small molecule inhibitors: implications for substrate specificity. Journal of Medicinal Chemistry. 52: 852-7
Huang R, Que X, Hirata K, et al. (2009) The cathepsin L of Toxoplasma gondii (TgCPL) and its endogenous macromolecular inhibitor, toxostatin. Molecular and Biochemical Parasitology. 164: 86-94
Stack CM, Caffrey CR, Donnelly SM, et al. (2008) Structural and functional relationships in the virulence-associated cathepsin L proteases of the parasitic liver fluke, Fasciola hepatica. The Journal of Biological Chemistry. 283: 9896-908
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