Thomas J Stout, PhD

Affiliations: 
1986-1992 Chemistry Cornell University, Ithaca, NY, United States 
 1992-1997 University of California, San Francisco, San Francisco, CA 
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"Thomas Stout"
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Parents

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Jon C. Clardy grad student 1986-1992 Cornell
Robert M. Stroud post-doc 1992-1997 UCSF
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Publications

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Brinen LS, Stout TJ. (2003) Can mosquitoes be bitten? A new hope for anti-malarial drug design. Structure (London, England : 1993). 11: 1309-10
Costi PM, Rinaldi M, Tondi D, et al. (1999) Phthalein derivatives as a new tool for selectivity in thymidylate synthase inhibition. Journal of Medicinal Chemistry. 42: 2112-24
Stout TJ, Tondi D, Rinaldi M, et al. (1999) Structure-based design of inhibitors specific for bacterial thymidylate synthase. Biochemistry. 38: 1607-17
Stout TJ, Schellenberger U, Santi DV, et al. (1998) Crystal structures of a unique thermal-stable thymidylate synthase from Bacillus subtilis. Biochemistry. 37: 14736-47
Sage CR, Michelitsch MD, Stout TJ, et al. (1998) D221 in thymidylate synthase controls conformation change, and thereby opening of the imidazolidine. Biochemistry. 37: 13893-901
Stout TJ, Sage CR, Stroud RM. (1998) The additivity of substrate fragments in enzyme-ligand binding. Structure (London, England : 1993). 6: 839-48
Sage CR, Rutenber EE, Stout TJ, et al. (1997) An essential role for water in an enzyme reaction mechanism: the crystal structure of the thymidylate synthase mutant E58Q. Biochemistry. 35: 16270-81
Stout TJ, Stroud RM. (1996) The complex of the anti-cancer therapeutic, BW1843U89, with thymidylate synthase at 2.0 A resolution: implications for a new mode of inhibition. Structure (London, England : 1993). 4: 67-77
Stout TJ, Costi MP, Barlocco D, et al. (1996) Structure-based discovery of a new class of enzyme inhibitors Acta Crystallographica Section a Foundations of Crystallography. 52: C207-C207
Sage CR, Rutenber EE, Stout TJ, et al. (1996) Short-circuiting a water-mediated enzyme reaction Acta Crystallographica Section a Foundations of Crystallography. 52: C239-C239
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