Jacques Dubochet

EMBL Heidelberg 
 University of Lausanne, Lausanne, Vaud, Switzerland 
 1973 University of Basel, Basel, Basel-Stadt, Switzerland 
cryo-electron microscopy, cryo-electron tomography, cryo-electron microscopy of vitreous sections
"Jacques Dubochet"

Jacques Dubochet (born 8 June 1942) is a retired Swiss biophysicist. He is a former employee of EMBL Heidelberg and a professor at the University of Lausanne (1987-2007). He got the Certificate of Molecular Biology at Geneva in 1969 and began to study electron microscopy of DNA. In 1973, he completed his thesis in biophysics at University of Geneva and University of Basel. He developed technologies in cryo-electron microscopy, cryo-electron tomography and cryo-electron microscopy of vitreous sections. These technologies are used to image individual biological structures such as protein complexes or virus particles.
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Cross-listing: StructuralBiologyTree


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Eduard Kellenberger grad student 1973 University of Basel


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Vsevolod Katritch post-doc 1995-1997 DBCM, Université de Lausanne, Switzerland (Computational Biology Tree)
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Dubochet J. (2018) On the Development of Electron Cryo-Microscopy (Nobel Lecture). Angewandte Chemie (International Ed. in English)
Dubochet J. (2012) Cryo-EM—the first thirty years Journal of Microscopy. 245: 221-224
Bleck CK, Merz A, Gutierrez MG, et al. (2010) Comparison of different methods for thin section EM analysis of Mycobacterium smegmatis. Journal of Microscopy. 237: 23-38
Demurtas D, Amzallag A, Rawdon EJ, et al. (2009) Bending modes of DNA directly addressed by cryo-electron microscopy of DNA minicircles. Nucleic Acids Research. 37: 2882-93
Eltsov M, Maclellan KM, Maeshima K, et al. (2008) Analysis of cryo-electron microscopy images does not support the existence of 30-nm chromatin fibers in mitotic chromosomes in situ. Proceedings of the National Academy of Sciences of the United States of America. 105: 19732-7
Zuber B, Chami M, Houssin C, et al. (2008) Direct visualization of the outer membrane of mycobacteria and corynebacteria in their native state Journal of Bacteriology. 190: 5672-5680
Leforestier A, Bertin A, Dubochet J, et al. (2008) Expression of chirality in columnar hexagonal phases or DNA and nucleosomes Comptes Rendus Chimie. 11: 229-244
Dubochet J, Zuber B, Eltsov M, et al. (2007) How to "read" a vitreous section. Methods in Cell Biology. 79: 385-406
Bouchet-Marquis C, Zuber B, Glynn AM, et al. (2007) Visualization of cell microtubules in their native state. Biology of the Cell. 99: 45-53
Amzallag A, Vaillant C, Jacob M, et al. (2006) 3D reconstruction and comparison of shapes of DNA minicircles observed by cryo-electron microscopy. Nucleic Acids Research. 34: e125
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