David E. Jane, PhD

Pharmacology University of Bristol, Bristol, England, United Kingdom 
Glutamate pharmacology and medicinal chemistry
"David Jane"
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Wang JX, Irvine MW, Burnell ES, et al. (2020) Structural basis of subtype-selective competitive antagonism for GluN2C/2D-containing NMDA receptors. Nature Communications. 11: 423
Sapkota K, Dore K, Tang K, et al. (2019) The NMDA receptor intracellular C-terminal domains reciprocally interact with allosteric modulators. Biochemical Pharmacology. 159: 140-153
Irvine MW, Fang G, Sapkota K, et al. (2018) Investigation of the structural requirements for N-methyl-D-aspartate receptor positive and negative allosteric modulators based on 2-naphthoic acid. European Journal of Medicinal Chemistry. 164: 471-498
Lodge D, Watkins JC, Bortolotto ZA, et al. (2018) The 1980s: D-AP5, LTP and a Decade of NMDA Receptor Discoveries. Neurochemical Research
Ingram R, Kang H, Lightman S, et al. (2018) Some distorted thoughts about ketamine as a psychedelic and a novel hypothesis based on NMDA receptor-mediated synaptic plasticity. Neuropharmacology
Burnell ES, Irvine MW, Fang G, et al. (2018) Positive and Negative Allosteric Modulators of N-Methyl-D-Aspartate (NMDA) Receptors; Structure-Activity Relationships and Mechanisms of Action. Journal of Medicinal Chemistry
Chopra DA, Sapkota K, Irvine MW, et al. (2017) A single-channel mechanism for pharmacological potentiation of GluN1/GluN2A NMDA receptors. Scientific Reports. 7: 6933
Sapkota K, Irvine MW, Fang G, et al. (2017) Mechanism and properties of positive allosteric modulation of N-methyl-d-aspartate receptors by 6-alkyl 2-naphthoic acid derivatives. Neuropharmacology
Safar F, Hurdiss E, Erotocritou M, et al. (2017) The startle disease mutation E103K impairs activation of human homomeric α1 glycine receptors by disrupting an intersubunit salt bridge across the agonist binding site. The Journal of Biological Chemistry
France G, Fernández-Fernández D, Burnell ES, et al. (2016) Multiple roles of GluN2B-containing NMDA receptors in synaptic plasticity in juvenile hippocampus. Neuropharmacology
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