David E. Jane, PhD

Pharmacology University of Bristol, Bristol, England, United Kingdom 
Glutamate pharmacology and medicinal chemistry
"David Jane"
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Wang JX, Irvine MW, Burnell ES, et al. (2020) Structural basis of subtype-selective competitive antagonism for GluN2C/2D-containing NMDA receptors. Nature Communications. 11: 423
Irvine MW, Fang G, Sapkota K, et al. (2018) Investigation of the structural requirements for N-methyl-D-aspartate receptor positive and negative allosteric modulators based on 2-naphthoic acid. European Journal of Medicinal Chemistry. 164: 471-498
Ingram R, Kang H, Lightman S, et al. (2018) Some distorted thoughts about ketamine as a psychedelic and a novel hypothesis based on NMDA receptor-mediated synaptic plasticity. Neuropharmacology
Sapkota K, Irvine MW, Fang G, et al. (2017) Mechanism and properties of positive allosteric modulation of N-methyl-d-aspartate receptors by 6-alkyl 2-naphthoic acid derivatives. Neuropharmacology
France G, Fernández-Fernández D, Burnell ES, et al. (2016) Multiple roles of GluN2B-containing NMDA receptors in synaptic plasticity in juvenile hippocampus. Neuropharmacology
Irvine MW, Fang G, Eaves R, et al. (2015) Synthesis of a Series of Novel 3,9-Disubstituted Phenanthrenes as Analogues of Known NMDA Receptor Allosteric Modulators. Synthesis. 47: 1593-1610
Wallis JL, Irvine MW, Jane DE, et al. (2015) An interchangeable role for kainate and metabotropic glutamate receptors in the induction of rat hippocampal mossy fiber long-term potentiation in vivo. Hippocampus
Volianskis A, France G, Jensen MS, et al. (2015) Long-term potentiation and the role of N-methyl-d-aspartate receptors. Brain Research
Shoemark DK, Williams C, Fahey MS, et al. (2015) Design and nuclear magnetic resonance (NMR) structure determination of the second extracellular immunoglobulin tyrosine kinase A (TrkAIg2) domain construct for binding site elucidation in drug discovery. Journal of Medicinal Chemistry. 58: 767-77
Irvine MW, Fang G, Eaves R, et al. (2015) Synthesis of a series of novel 3,9-disubstituted phenanthrenes as analogues of known N-methyl-D-aspartate receptor allosteric modulators Synthesis (Germany). 47: 1593-1610
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