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Edward J. Miracco, Ph.D.

Affiliations: 
Chemistry and Biochemistry University of California, Los Angeles, Los Angeles, CA 
Area:
Structural Biochemistry
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"Edward Miracco"
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Parents

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Eugene G. Mueller grad student 2005-2011 University of Delaware
 (Mechanistic studies of the pseudouridine synthases TruB and RluA and their interaction with 5-fluorouridine.)
Juli Feigon post-doc 2011- UCLA

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Publications

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Nelson J, Sorensen EW, Mintri S, et al. (2020) Impact of mRNA chemistry and manufacturing process on innate immune activation. Science Advances. 6: eaaz6893
Jiang J, Chan H, Cash DD, et al. (2015) Structure of Tetrahymena telomerase reveals previously unknown subunits, functions, and interactions. Science (New York, N.Y.). 350: aab4070
Miracco EJ, Jiang J, Cash DD, et al. (2014) Progress in structural studies of telomerase. Current Opinion in Structural Biology. 24: 115-24
Jiang J, Miracco EJ, Hong K, et al. (2014) Erratum: Corrigendum: The architecture of Tetrahymena telomerase holoenzyme Nature. 506: 254-254
Hong K, Upton H, Miracco EJ, et al. (2013) Tetrahymena telomerase holoenzyme assembly, activation, and inhibition by domains of the p50 central hub. Molecular and Cellular Biology. 33: 3962-71
Jiang J, Miracco EJ, Hong K, et al. (2013) The architecture of Tetrahymena telomerase holoenzyme. Nature. 496: 187-92
Miracco EJ, Bogdanov B, Mueller EG. (2011) Unexpected linear ion trap collision-induced dissociation and Fourier transform ion cyclotron resonance infrared multi-photon dissociation fragmentation of a hydrated C-glycoside of 5-fluorouridine formed by the action of the pseudouridine synthases RluA and TruB. Rapid Communications in Mass Spectrometry : Rcm. 25: 2627-32
Miracco EJ, Mueller EG. (2011) The products of 5-fluorouridine by the action of the pseudouridine synthase TruB disfavor one mechanism and suggest another. Journal of the American Chemical Society. 133: 11826-9
McDonald MK, Miracco EJ, Chen J, et al. (2011) The handling of the mechanistic probe 5-fluorouridine by the pseudouridine synthase TruA and its consistency with the handling of the same probe by the pseudouridine synthases TruB and RluA. Biochemistry. 50: 426-36
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