Julian Blagg, PhD/ BA
Affiliations: | 2007- | Chemistry | Institute of Cancer Research, London, UK |
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Children
Sign in to add trainee| Mark A Honey | post-doc | Institute of Cancer Research, London, UK | |
| Mark G McLaughlin | post-doc | ||
| Catherine Tighe | post-doc | 2018- | Institute of Cancer Research (CSD Tree) |
| Andrew G. Malcolm | post-doc | 2016-2018 | Institute of Cancer Research |
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Publications
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| Moore AS, Faisal A, Mak GWY, et al. (2020) Quizartinib-resistant FLT3-ITD acute myeloid leukemia cells are sensitive to the FLT3-Aurora kinase inhibitor CCT241736. Blood Advances. 4: 1478-1491 |
| Anderhub SJ, Mak GW, Gurden MD, et al. (2019) High Proliferation Rate and a Compromised Spindle Assembly Checkpoint Confers Sensitivity to the MPS1 Inhibitor BOS172722 in Triple-Negative Breast Cancers. Molecular Cancer Therapeutics. 18: 1696-1707 |
| Romo-Morales A, Aladowicz E, Blagg J, et al. (2019) Catalytic inhibition of KDM1A in Ewing sarcoma is insufficient as a therapeutic strategy. Pediatric Blood & Cancer. e27888 |
| Le Bihan YV, Lanigan RM, Atrash B, et al. (2019) C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays. European Journal of Medicinal Chemistry. 177: 316-337 |
| Gilburt JAH, Girvan P, Blagg J, et al. (2019) Ligand discrimination between active and inactive activation loop conformations of Aurora-A kinase is unmodified by phosphorylation. Chemical Science. 10: 4069-4076 |
| Wood F, Shepherd S, Hayes A, et al. (2019) Metabolism of the dual FLT-3/Aurora kinase inhibitor CCT241736 in preclinical and human in vitro models: Implication for the choice of toxicology species. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences |
| Calpena E, Hervieu A, Kaserer T, et al. (2019) De Novo Missense Substitutions in the Gene Encoding CDK8, a Regulator of the Mediator Complex, Cause a Syndromic Developmental Disorder. American Journal of Human Genetics |
| Sharifnia T, Wawer MJ, Chen T, et al. (2019) Small-molecule targeting of brachyury transcription factor addiction in chordoma. Nature Medicine |
| Meyers J, Chessum NEA, Ali S, et al. (2018) Privileged Structures and Polypharmacology within and between Protein Families. Acs Medicinal Chemistry Letters. 9: 1199-1204 |
| Vazquez-Rodriguez S, Wright M, Rogers CM, et al. (2018) Design, Synthesis and Characterization of Covalent KDM5 Inhibitors. Angewandte Chemie (International Ed. in English) |