Julian Blagg, PhD/ BA

2007- Chemistry Institute of Cancer Research, London, UK 
"Julian Blagg"
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Moore AS, Faisal A, Mak GWY, et al. (2020) Quizartinib-resistant FLT3-ITD acute myeloid leukemia cells are sensitive to the FLT3-Aurora kinase inhibitor CCT241736. Blood Advances. 4: 1478-1491
Anderhub SJ, Mak GW, Gurden MD, et al. (2019) High Proliferation Rate and a Compromised Spindle Assembly Checkpoint Confers Sensitivity to the MPS1 Inhibitor BOS172722 in Triple-Negative Breast Cancers. Molecular Cancer Therapeutics. 18: 1696-1707
Romo-Morales A, Aladowicz E, Blagg J, et al. (2019) Catalytic inhibition of KDM1A in Ewing sarcoma is insufficient as a therapeutic strategy. Pediatric Blood & Cancer. e27888
Le Bihan YV, Lanigan RM, Atrash B, et al. (2019) C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays. European Journal of Medicinal Chemistry. 177: 316-337
Gilburt JAH, Girvan P, Blagg J, et al. (2019) Ligand discrimination between active and inactive activation loop conformations of Aurora-A kinase is unmodified by phosphorylation. Chemical Science. 10: 4069-4076
Wood F, Shepherd S, Hayes A, et al. (2019) Metabolism of the dual FLT-3/Aurora kinase inhibitor CCT241736 in preclinical and human in vitro models: Implication for the choice of toxicology species. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences
Calpena E, Hervieu A, Kaserer T, et al. (2019) De Novo Missense Substitutions in the Gene Encoding CDK8, a Regulator of the Mediator Complex, Cause a Syndromic Developmental Disorder. American Journal of Human Genetics
Sharifnia T, Wawer MJ, Chen T, et al. (2019) Small-molecule targeting of brachyury transcription factor addiction in chordoma. Nature Medicine
Meyers J, Chessum NEA, Ali S, et al. (2018) Privileged Structures and Polypharmacology within and between Protein Families. Acs Medicinal Chemistry Letters. 9: 1199-1204
Vazquez-Rodriguez S, Wright M, Rogers CM, et al. (2018) Design, Synthesis and Characterization of Covalent KDM5 Inhibitors. Angewandte Chemie (International Ed. in English)
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